Authors: Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Taheri MM PMID: 25561919 PMCID: PMC4277626 Abstract Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Anti-diabetic, hypolipidemic and anti-oxidative properties of ginger have been noticed in several researches. The present study [...]

Authors: Lee CR, Zeldin DC PMID: 26605933 PMCID: PMC5512422 DOI: 10.1056/NEJMcibr1511280 Abstract Newly discovered antiinflammatory molecules, dubbed resolvins, accelerate the resolution of inflammation in mice infected with E. coli and increase their survival. Source: https://www.nejm.org/doi/full/10.1056/NEJMcibr1511280 Archive: https://archive.is/5m1RU

Authors: Akagawa M, Nakano M, Ikemoto K PMID: 26168402 DOI: 10.1080/09168451.2015.1062715 Abstract Pyrroloquinoline quinone (PQQ), an aromatic tricyclic o-quinone, was identified initially as a redox cofactor for bacterial dehydrogenases. Although PQQ is not biosynthesized in mammals, trace amounts of PQQ have been found in human and rat tissues because of its wide distribution in dietary [...]

Authors: Yoshihara T, Shimada K, Fukao K, Sai E, Matsumori R, Alshahi H PMID: 25925976 DOI: 10.1253/circj.CJ-14-0471 Abstract Background: Dietary intake of ω3 polyunsaturated fatty acids (ω3-PUFAs) reduces progression of atherosclerosis and prevents future cardiovascular events. Macrophages are key players in the pathogenesis of aortic aneurysm. The effects of ω3-PUFAs on abdominal aortic aneurysm [...]

Authors: Serhan CN PMID: 24899309 PMCID: PMC4263681 doi: 10.1038/nature13479 Abstract Advances on mechanisms in resolution of acute inflammation uncovered a new genus of pro-resolving lipid mediators that include separate families of molecules: lipoxins, resolvins, protectins and maresins, collectively coined specialized pro-resolving mediators (SPM). Synthetic SPM possess potent bioactions when administered in vivo. In animal experiments, [...]

Authors: Weng Z, Patel AB, Panagiotidou S, Theoharides TC PMID: 25498791 PMCID: PMC4388775 DOI: 10.1016/j.jaci.2014.10.032 Abstract Background: Mast cells (MCs) are hematopoietic cells that mature in tissues and are involved in allergy, immunity, and inflammation by secreting multiple mediators. The natural flavone luteolin has anti-inflammatory actions and inhibits human mast cells (MCs). Objective: We sought [...]

Authors: Hine C, Mitchell JR PMID: 24905161 PMCID: PMC4278638 DOI: 10.1016/j.stem.2014.05.016 Abstract Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic [...]

Authors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal [...]

Authors: Younger J, Parkitny L, McLain D PMID: 24526250 PMCID: PMC3962576 DOI: 10.1007/s10067-014-2517-2 Abstract Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous [...]

Authors: Houghton CA, Fassett RG, Coombes JS PMID: 24147970 DOI: 10.1111/nure.12060 Abstract Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in humans, but they are not generally consumed at levels that effect significant change in biomarkers of health. Because consumers have embraced the notion that dietary supplements may prevent disease, this review considers whether [...]