Authors: Pistollato F, Masias M, Agudo P, Giampieri F. PMID: 30381840 DOI: 10.1111/nyas.13980 Abstract About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, [...]

Cutaneous adverse reactions to medications are extremely common and display characteristic clinical morphology. A fixed drug eruption is a cutaneous adverse drug reaction due to type IV or delayed cell-mediated hypersensitivity. Ivermectin, a broad-spectrum anti-parasitic compound, has been an essential component of public health campaigns targeting the control of two devastating neglected tropical diseases: onchocerciasis (river blindness) and lymphatic filariasis.

Authors: Marik PE PMID: 29684467 DOI: 10.1016/j.pharmthera.2018.04.007 Abstract Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions. Sepsis results in the overwhelming production of reactive oxygen species with [...]

Authors: Kim DH, Jeong D, Kim H, Seo KH. PMID: 29336590 DOI: 10.1080/10408398.2018.1428168 Abstract Kefir is a natural complex fermented milk product containing more than 50 species of probiotic bacteria and yeast, and has been demonstrated to have multiple properties conferring health benefits, including antiobesity, anti-hepatic steatosis, antioxidative, antiallergenic, antitumor, anti-inflammatory, cholesterol-lowering, constipation-alleviating, and antimicrobial [...]

Authors: Nieman DC, Ramamoorthy S, Kay CD, Goodman CL, Capps CR, Shue ZL. PMID: 28631923 DOI: 10.1021/acs.jproteome.7b00196 Abstract This study evaluated the effect of ingesting a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults using untargeted metabolomics procedures. Participants (N = 103, 18-65 y, BMI ≥ [...]

Authors: Cialdella-Kam L, Ghosh S, Meaney MP, Knab AM, Shanely RA, Nieman DC. PMID: 28753942 PMCID: PMC5537887 DOI: 10.3390/nu9070773 Abstract Quercetin (Q) and green tea extract (E) are reported to counter insulin resistance and inflammation and favorably alter fat metabolism. We investigated whether a mixture of E + Q (EQ) could synergistically influence metabolic and [...]

Authors:Rosing CK, Cavagni J, Gaio EJ, Muniz FW, Ranzan N. PMID:28678966 DOI: 10.1590/1807-3107BOR-2017.vol31.0047 Abstract This study aimed to evaluate the anti-plaque and anti-gingivitis effects of two mouthwashes containing cetylpyridinium chloride (CPC), in comparison to negative control mouthwash. One hundred and twenty subjects were randomly assigned to study groups: test (0.075% CPC and 0.28% zinc lactate), [...]

Authors: Warner ME, Naranjo J, Pollard EM, Weingarten TN, Warner MA. PMID: 28667541 DOI: 10.1007/s12630-017-0918-9 Abstract Purpose: Perioperative use of serotonergic agents increases the risk of serotonin syndrome. We describe the occurrence of serotonin syndrome after fentanyl use in two patients taking multiple serotonergic agents. Clinical features: Two patients who had been taking multiple serotonergic [...]

Authors: Schwalfenberg GK. PMID: PMC5494092 DOI: 10.1155/2017/6254836 Abstract Objective: To review the evidence for the use of vitamin K supplementation in clinical conditions such as osteoporosis, vascular calcification, arthritis, cancer, renal calculi, diabetes, and warfarin therapy. Quality of evidence: PubMed was searched for articles on vitamin K (K1 and K2) along with books and conference [...]

Stevens–Johnson syndrome is one of the manifestations of mucocutaneous adverse drug reactions. Although antimicrobials are responsible for greater than 50% of these adverse drug reactions, there is no documented case implicating ivermectin as the culprit.