Authors:Rhodes JM, Subramanian S, Laird E, Kenny RA. PMID:PMC7264531 DOI: 10.1111/apt.15777 Abstract Keywords: Source: https://pubmed.ncbi.nlm.nih.gov/32311755/ Archive: https://archive.is/hP7pW

Authors:Lau FH, Majumder R, Torabi R, Saeg F, Hoffman R, Cirillo JD. doi: https://doi.org/10.1101/2020.04.24.20075838 Abstract Background COVID-19 is a major pandemic that has killed more than 196,000 people. The COVID-19 disease course is strikingly divergent. Approximately 80-85% of patients experience mild or no symptoms, while the remainder develop severe disease. The mechanisms underlying these divergent [...]

Authors: Hashem HE. DOI: 10.14744/ejmo.2020.36102 Abstract Objectives: The emergence and spread of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), led researchers around the world to study the crystal structure of the main protease (Mpro), 3-chymotrypsin-like cysteine protease, which is an essential enzyme for processing polyproteins. Inhibition of this [...]

Authors: Kandeel M, Al-Nazawi M. PMID: 32251634 PMCID: PMC7194560 DOI: 10.1016/j.lfs.2020.117627 Abstract Aims: In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs dataset. In addition, a knowledge gap [...]

Authors:Grant WB, Lahore H, McDonnell SL, Baggerly CA, French Cb, Aliaono JL. PMID:PMC7231123 DOI: 10.3390/nu12040988 Abstract The world is in the grip of the COVID-19 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. This article reviews the roles of vitamin D in reducing [...]

Authors: Salim B, Noureddine M. PMID: DOI:10.26434/chemrxiv.12055716.v1 Abstract The spread of the global COVID-19 pandemic, the lack of specific treatment and the urgent situation requires use of all resources to remedy this scourge. In the present study, using molecular docking, we identify new probable inhibitors of COVID-19 by molecules from Nigella sativa L, which is [...]

Sepsis commonly progresses to disseminated intravascular coagulation and induces the activation of heparanase (HPA) and the shedding of endothelial glycocalyx constituents, including syndecan-1 (SDC-1) and heparan sulphate (HS). However, the degradation of glycocalyx and its association with coagulation disorders remains undetermined.

Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO), and despite decades of research, novel initiatives are drastically needed. According to the current literature, oxidative imbalance and mitochondrial dysfunction are common features of septic patients that can cause multiorgan failure and death. Melatonin, alongside its traditionally accepted role as the master hormonal regulator of the circadian rhythm, is a promising adjunctive drug for sepsis through its anti-inflammatory, antiapoptotic and powerful antioxidant properties. Several animal models of sepsis have demonstrated that melatonin can prevent multiorgan dysfunction and improve survival through restoring mitochondrial electron transport chain (ETC) function, inhibiting nitric oxide synthesis and reducing cytokine production. The purpose of this article is to review the current evidence for the role of melatonin in sepsis, review its pharmacokinetic profile and virtual absence of side effects. While clinical data is limited, we propose the adjunctive use of melatonin is patients with severe sepsis and septic shock.

Authors: Moballegh Nasery M, Abadi B, Poormoghadam D, Zarrabi A, Keyhanvar P, Tavakol S et al. PMID: PMC7037405 DOI: 10.3390/molecules25030689 Abstract Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such [...]

Authors: Chai YS, Chen YQ, Lin SH, Xie K, Wang CJ, Yang YZ. PMID: 32004976 DOI: 10.1016/j.biopha.2020.109946 Abstract Objectives: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. Curcumin has been reported to be an anti-inflammatory factor through enhancing the function [...]