Auhtors: Das A, Durrant D, Alloum FN, Xi L, Kukreja RC PMID: 25444755 PMCID: PMC4494657 DOI: 10.1016/j.pharmthera.2014.10.003 Abstract The phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra™), vardenafil (Levitra™), and tadalafil (Cialis™) have been developed for treatment of erectile dysfunction. Moreover, sildenafil and tadalafil are used for the management of pulmonary arterial hypertension in patients. Since [...]

Auhtors: Garcia DO, Thomson CA PMID: 25335787 PMCID: PMC4470419 DOI: 10.1177/0884533614551969 Abstract There has been an increase in the cancer survivor population in the United States over the past several decades primarily due to improvements in early detection of first malignancies and effective treatment modalities. A wealth of evidence has demonstrated that regular physical activity [...]

Auhtors: Bourdel-Marchasson I, Blanc-Bisson C, Doussau A, Germain C, Blanc JF, Dauba J, et al. PMID: 25265392 PMCID: PMC4181649 DOI: 10.1371/journal.pone.0108687 Abstract Objective: We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality. Method: We conducted a multicentre, open-label [...]

Auhtors: Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, et al. PMID: 25228990 PMCID: PMC4165433 DOI: 10.1186/2049-3002-2-18 Abstract Background: Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known as cancer cachexia. [...]

Auhtors: Petsiou EI, Mitrou PI, Raptis SA, Dimitriadis GD PMID: 25168916 DOI: 10.1111/nure.12125 Abstract The aim of this review is to summarize the effects of vinegar on glucose and lipid metabolism. Several studies have demonstrated that vinegar can help reduce hyperglycemia, hyperinsulinemia, hyperlipidemia, and obesity. Other studies, however, have shown no beneficial effect on metabolism. [...]

Auhtors: Beury DW, Parker KH, Nyandjo M, Sinha P, Carter KA, Ostrand-Rosenberg S PMID: 25170116 PMCID: PMC4226789 DOI: 10.1189/jlb.3A0414-210R Abstract MDSC and macrophages are present in most solid tumors and are important drivers of immune suppression and inflammation. It is established that cross-talk between MDSC and macrophages impacts anti-tumor immunity; however, interactions between tumor cells [...]

Auhtors: Urbinello D, Joseph W, Verloock L, Martens L, Röösli M PMID: 25127524 DOI: 10.1016/j.envres.2014.07.003 Abstract Background: The rapid development and increased use of wireless telecommunication technologies led to a substantial change of radio-frequency electromagnetic field (RF-EMF) exposure in the general population but little is known about temporal trends of RF-EMF in our everyday environment. [...]

Auhtors: Bannister CA, Holden SE, Jenkins-Jones S, Morgan CL, Halcox JP, Schernthaner G, et al. PMID: 25041462 DOI: 10.1111/dom.12354 Abstract Aims: Clinical and observational studies have shown an increased risk of cardiovascular events and death associated with sulphonylureas versus metformin. However, it has never been determined whether this was due to the beneficial effects of [...]

Auhtors: Labelle M, Begum S, Hynes RO PMID: 25024172 PMCID: PMC4121772 DOI: 10.1073/pnas.1411082111 Abstract During metastasis, host cells are recruited to disseminated tumor cells to form specialized microenvironments ("niches") that promote metastatic progression, but the mechanisms guiding the assembly of these niches are largely unknown. Tumor cells may autonomously recruit host cells or, alternatively, host [...]

Auhtors: Gandini S, Puntoni M, Heckman-Stoddard BM, Dunn BK, Ford L, DeCensi A, Szabo E PMID: 24985407 PMCID: PMC4154969 DOI: 10.1158/1940-6207.CAPR-13-0424 Abstract Previous meta-analyses have shown that the antidiabetic agent metformin is associated with reduced cancer incidence and mortality. However, this effect has not been consistently demonstrated in animal models and recent epidemiologic studies. We [...]