Auhtors: Meynet O, Ricci JE PMID: 24916302 DOI: 10.1016/j.molmed.2014.05.001 Abstract Caloric restriction (CR) is currently the most robust environmental intervention known to increase healthy life and prolong lifespan in several models, from yeast to mice. Although the protective effect of CR on the incidence of cancer is well established, its impact on tumor cell responses [...]

Auhtors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS. PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction [...]

Auhtors: Teicholz N Abstract In The Big Fat Surprise, investigative journalist Nina Teicholz reveals the unthinkable: that everything we thought we knew about dietary fat is wrong. She documents how the low-fat nutrition advice of the past 60 years has amounted to a vast uncontrolled experiment on the entire population, with disastrous consequences for our [...]

Auhtors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC, Fuchs CS PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]

Auhtors: Anglemyer A, Horvath HT, Bero L PMID: 24782322 PMCID: PMC8191367 DOI: 10.1002/14651858.MR000034.pub2 Abstract Background: Researchers and organizations often use evidence from randomized controlled trials (RCTs) to determine the efficacy of a treatment or intervention under ideal conditions. Studies of observational designs are often used to measure the effectiveness of an intervention in 'real world' [...]

Auhtors: Bradbury KE, Balkwill A, Spencer EA, Roddam AW, Reeves GK, Green J, et al. PMID: 24675385 PMCID: PMC4007233 DOI: 10.1038/bjc.2014.148 Abstract Background: Organically produced foods are less likely than conventionally produced foods to contain pesticide residues. Methods: We examined the hypothesis that eating organic food may reduce the risk of soft tissue sarcoma, breast [...]

Auhtors: Nowis D, Malenda A, Furs K, Oleszczak B, Sadowski R, Chlebowska J, et al. PMID: 25452863 PMCID: PMC4212557 DOI: 10.1136/bmjdrc-2014-000017 Abstract Objective: Considering the increasing number of clinical observations indicating hyperglycemic effects of statins, this study was designed to measure the influence of statins on the uptake of glucose analogs by human cells derived [...]

Auhtors: Bernstein J Abstract Big Pharma’s focus on blockbuster cancer drugs squeezes out research into potential treatments that are more affordable. Says one researcher: “What is scientific and sexy is driven by what can be monetized.” Source: https://www.propublica.org/article/where-are-the-low-cost-cancer-treatments Archive: https://archive.is/ZAKcn

Auhtors: Lindqvist PG, Epstein E, Landin-Olsson M, Ingvar C, Nielsen K, stenbeck M, Olsson H PMID: 24697969 DOI: 10.1111/joim.12251 Abstract Background: Sunlight exposure and fair skin are major determinants of human vitamin D production, but they are also risk factors for cutaneous malignant melanoma (MM). There is epidemiological evidence that all-cause mortality is related to [...]

Auhtors: Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, et al. PMID: 24690623 PMCID: PMC3972416 DOI: 10.1136/bmj.g1903 Abstract Objective: To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances. Design: Systematic review and meta-analysis of [...]