Auhtors: Shakya G, Balasubramanian S, Rajagopalan R PMID: 26109759 PMCID: PMC4461953 DOI: 10.4103/0973-1296.157715 Abstract Background: Deregs been implicated in the malignancy of cancer. Since many years investigation on the traditional herbs has been the focus to develop novel and effective drug for cancer remedies. Wheatgrass is a medicinal plant, used in folk medicine to cure [...]

Auhtors: Ruffell B, Coussens LM. PMID: 25858805 PMCID: PMC4400235 DOI: 10.1016/j.ccell.2015.02.015 Abstract How neoplastic cells respond to therapy is not solely dependent on the complexity of the genomic aberrations they harbor but is also regulated by numerous dynamic properties of the tumor microenvironment. Identifying and targeting critical pathways that improve therapeutic efficacy by bolstering anti-tumor [...]

Auhtors: Meidenbauer JJ, Mukherjee P, Seyfried TN Abstract Background Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain [...]

Auhtors: Lahart IM, Metsios GS, Nevill AM, Carmichael AR PMID: 25752971 DOI: 10.3109/0284186X.2014.998275 Abstract Strong evidence exists supporting the effect of lack of physical activity on the risk of developing breast cancer. However, studies examining the effects of physical activity on breast cancer outcomes, including survival and prognosis have been inconclusive. Therefore, the aim of [...]

Auhtors: Zitvogel L, Galluzzi L, Viaud S, Vétizou M, Daillère R, Merad M, Kroemer G PMID: 25609166 PMCID: PMC4690201 DOI: 10.1126/scitranslmed.3010473 Abstract Changes in the interactions among the gut microbiota, intestinal epithelium, and host immune system are associated with many diseases, including cancer. We discuss how environmental factors infuence this cross-talk during oncogenesis and tumor [...]

Auhtors: Savage P PMID: 25605631 PMCID: PMC4308945 DOI: 10.1186/s12885-015-1006-6 Abstract Background: A select number of relatively rare metastatic malignancies comprising trophoblast tumours, the rare childhood cancers, germ cells tumours, leukemias and lymphomas have been routinely curable with chemotherapy for more than 30 years. However for the more common metastatic malignancies chemotherapy treatment frequently brings clinical [...]

Auhtors: Hirshkowitz M, Whiton K, Albert SM, Alessi C, Bruni O, DonCarlos L, et al. PMID: 29073412 DOI: 10.1016/j.sleh.2014.12.010 Abstract Objective: The objective was to conduct a scientifically rigorous update to the National Sleep Foundation's sleep duration recommendations. Methods: The National Sleep Foundation convened an 18-member multidisciplinary expert panel, representing 12 stakeholder organizations, to evaluate [...]

Auhtors: Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, et al. PMID: 25470039 PMCID: PMC4465385 DOI: 10.1038/nature14034 Abstract Cytotoxic chemotherapy is effective in debulking tumour masses initially; however, in some patients tumours become progressively unresponsive after multiple treatment cycles. Previous studies have demonstrated that cancer stem cells (CSCs) are selectively enriched [...]

Auhtors: Pantziarka P, Bouche G, Meheus L, Sukhatme V, Sukhatme VP PMID: 25525463 PMCID: PMC4268104 DOI: 10.3332/ecancer.2014.485 Abstract Cimetidine, the first H2 receptor antagonist in widespread clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical and clinical studies for a number of different cancer types. These data are summarised [...]

Auhtors: Larsen AR, Bai RY, Chung JH, Borodovsky A, Rudin CM, Riggins GJ, Bunz F PMID: 25376612 PMCID: PMC4297232 DOI: 10.1158/1535-7163.MCT-14-0755-T Abstract The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. Here, we show that mebendazole, a benzamidazole with a long history [...]