Auhtors: Wang J, Nie D DOI: 10.5772/61484 Abstract Fatty acids are important molecules with multiple biological properties. Emerging evidence suggests that fatty acids can modulate autophagy. Saturated fatty acids contribute to pancreatic β-cell dysfunction in type 2 diabetes. Palmitic acid, one of the long-chain saturated fatty acids (LCFA), induces autophagy of β-cells which protects them [...]

Auhtors: Huang Z, Wu T, Liu AY, Ouyang G PMID: 26474460 PMCID: PMC4741845 DOI: 10.18632/oncotarget.6098 Abstract Tumor cells actively contribute to constructing their own microenvironment during tumorigenesis and tumor progression. The tumor microenvironment contains multiple types of stromal cells that work together with the extracellular matrix and local and systemic factors to coordinately contribute to [...]

Auhtors: Daniels K, Daugherty J, Jones J, Mosher W PMID: 26556545 Abstract This report describes current contraceptive use among women of childbearing age (ages 15-44) during 2011-2013. Current contraceptive use is defined as use during the month of interview, not for a specific act of sexual intercourse. This report's primary focus is describing patterns of [...]

Auhtors: Mei XL, Yang Y, Zhang YJ, Li Y, Zhao JM, Qiu JG, et al. PMID: 26807313 PMCID: PMC4697679 Abstract Colorectal cancer is the third most common human cancer with frequent overexpression of the cGMP-specific phosphodiesterase 5 (PDE5). In the present study, we investigated that the anticancer effect of sildenafil on human colorectal cancer in [...]

Auhtors: Hoyos C, Glozier N, Marshall NS Abstract It is often claimed that we are living through a global sleep loss epidemic where, as a society, we increasingly get less and less sleep. However, our previously published systematic review of all relevant studies until May 2011 failed to find strong evidence that this had happened [...]

Auhtors: Condamine T, Mastio J, Gabrilovich DI PMID: 26337512 PMCID: PMC4661041 DOI: 10.1189/jlb.4RI0515-204R Abstract Myeloid-derived suppressor cells are a heterogeneous group of pathologically activated immature cells that play a major role in the negative regulation of the immune response in cancer, autoimmunity, many chronic infections, and inflammatory conditions, as well as in the regulation of [...]

Auhtors: Rebello CJ, Burton J, Heiman M, Greenway FL. PMID: 26424589 PMCID: PMC4656110 DOI: 10.1016/j.jdiacomp.2015.08.023 Abstract Objective: The objective of this study was to examine the effects of a gastrointestinal microbiome modulator (GIMM) containing inulin, β-glucan, blueberry anthocyanins, and blueberry polyphenols on metabolic parameters, fecal markers of gut microbiota, and satiety. Design and methods: [...]

Auhtors: Boursi B, Mamtani R, Haynes K, Yang YX PMID: 26338196 PMCID: PMC4663115 DOI: 10.1016/j.ejca.2015.08.015 Abstract Background: Bacterial dysbiosis was previously described in human malignancies. In a recent animal model, tumour susceptibility was transmitted using faecal transplantation. Our aim was to evaluate possible association between antibiotic exposure and cancer risk. Methods: We conducted nested case-control [...]

Auhtors: Scoccianti C, Key TJ, Anderson AS, Armaroli P, Berrino F, Cecchini M, et al. PMID: 26116994 DOI: 10.1016/j.canep.2014.12.007 Abstract Breast cancer is the most frequent cancer in women, and incidence rates have been rising in European Union (EU) countries over recent decades due in part to a sharp decline in breastfeeding practices. Evidence for [...]

Auhtors: Ng K, Venook AP, Sato K, Yuan C, Hollis BW, Chang IW, et al. doi: https://doi.org/10.1200/jco.2015.33.15_suppl.3503 Abstract Background: Prospective epidemiologic data suggest that higher levels of 25-hydroxyvitamin D [25(OH)D] are associated with improved survival in patients with colorectal cancer, however the relationship between 25(OH)D and outcome in metastatic CRC (mCRC), specifically, is unknown. Methods: [...]