Auhtors: Zhan T, Rindtorff N, Boutros M PMID: 27617575 PMCID: PMC5357762 DOI: 10.1038/onc.2016.304 Abstract Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed [...]

Auhtors: Matthan NR, Ausman LM, Meng H, Tighiouart H, Lichtenstein AH PMID: 27604773 PMCID: PMC5039811 DOI: 10.3945/ajcn.116.137208 Abstract Background: The utility of glycemic index (GI) values for chronic disease risk management remains controversial. Although absolute GI value determinations for individual foods have been shown to vary significantly in individuals with diabetes, there is a dearth [...]

Auhtors: Itani O, Jike M, Watanabe N, Kaneita Y PMID: 27743803 DOI: 10.1016/j.sleep.2016.08.006 Abstract Objective: The dose-response of short sleep duration in mortality has been studied, in addition to the incidences of notable health complications and diseases such as diabetes mellitus, hypertension, cardiovascular diseases, stroke, coronary heart diseases, obesity, depression, and dyslipidemia. Methods: We collected [...]

Auhtors: Marinac CR, Nelson SH, Breen CI, Hartman SJ, Natarajan L, Pierce JP, et al. PMID: 27032109 PMCID: PMC4982776 DOI: 10.1001/jamaoncol.2016.0164 Abstract Importance: Rodent studies demonstrate that prolonged fasting during the sleep phase positively influences carcinogenesis and metabolic processes that are putatively associated with risk and prognosis of breast cancer. To our knowledge, no studies [...]

Auhtors: Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, et al. PMID: 27409811 DOI: 10.1038/nature18646 Abstract Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish [...]

Auhtors: Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, et al. PMID: 27381735 PMCID: PMC4935811 DOI: 10.1038/ncomms12150 Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both [...]

Auhtors: Nassar D, Blanpain C PMID: 27193450 DOI: 10.1146/annurev-pathol-012615-044438 Abstract Different mechanisms contribute to intratumor heterogeneity, including genetic mutations, the microenvironment, and the existence of subpopulations of cancer cells with increased renewal capacity and the ability to recapitulate the heterogeneity found in primary tumors, which are referred to as cancer stem cells (CSCs). In this [...]

Auhtors: Creed SA Abstract We've been told for years that eating fat is bad for us, that it is a primary cause of high blood pressure, heart disease and obesity. The Real Meal Revolution debunks this lie and shows us the way back to restored health through eating what human beings are meant to eat. [...]

Auhtors: Keadle SK, McKinnon R, Graubard BI, Troiano RP PMID: 27196146 PMCID: PMC4969157 DOI: 10.1016/j.ypmed.2016.05.009 Abstract This paper examined how many older adults (65+years) are meeting physical activity (PA) Guidelines (PAG; 150min/week of moderate-to-vigorous PA) using data from three leading national surveys (NHANES, BRFSS and NHIS). The proportion of individuals meeting aerobic PAG was determined [...]

Auhtors: Ramsden CE, Zamora D, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A PMID: 27071971 PMCID: PMC4836695 DOI: 10.1136/bmj.i1246 Abstract Objective: To examine the traditional diet-heart hypothesis through recovery and analysis of previously unpublished data from the Minnesota Coronary Experiment (MCE) and to put findings in the context of existing diet-heart randomized controlled [...]