Auhtors: Antoni R, Johnston KL, Collins AL, Robertson MD. PMID: 28091348 DOI: 10.1017/S0029665116002986 Abstract Two intermittent fasting variants, intermittent energy restriction (IER) and time-restricted feeding (TRF), have received considerable interest as strategies for weight-management and/or improving metabolic health. With these strategies, the pattern of energy restriction and/or timing of food intake are altered so that [...]

Auhtors: Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, et al. PMID: 28346153 DOI: 10.1016/j.sleh.2016.11.006 Abstract Objectives: To provide evidence-based recommendations and guidance to the public regarding indicators of good sleep quality across the life-span. Methods: The National Sleep Foundation assembled a panel of experts from the sleep community and representatives [...]

Authors: Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J PMID: 27940189 DOI: 10.1016/j.chest.2016.11.036 Abstract Background: The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. Methods: In this retrospective before-after clinical study, we compared the outcome and clinical course of [...]

Auhtors: Zou K, Zhao L, Young A, Zhand H-Y, Li B, Zhu W-L, et al. PMID: 27917872 PMCID: PMC5309756 DOI: 10.1038/aps.2016.125 Abstract It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid [...]

Auhtors: Sung MM, Kim TT, Denou E, Soltys CL, Hamza SM, Byrne NJ, et al. PMID: 27903747 DOI: 10.2337/db16-0680 Abstract Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes [...]

Auhtors: Mattson MP, Longo VD, Harvie M PMID: 27810402 PMCID: PMC5411330 DOI: 10.1016/j.arr.2016.10.005 Abstract Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when [...]

Auhtors: Liu Y, Fang S, Sun Q, Liu B PMID: 27771251 DOI: 10.1016/j.bbrc.2016.10.064 Abstract Glioblastoma is one of the most vascular brain tumour and highly resistant to current therapy. Targeting both glioblastoma cells and angiogenesis may present an effective therapeutic strategy for glioblastoma. In our work, we show that an anthelmintic drug, ivermectin, is active [...]

Auhtors: Zhang L, Xu L, Zhang F, Vlashi E PMID: 27753527 PMCID: PMC5405729 DOI: 10.1080/15384101.2016.1241929 Abstract Experimental evidence suggest that breast tumors originate from breast cancer stem cells (BCSCs), and that mitochondrial biogenesis is essential for the anchorage-independent clonal expansion and survival of CSCs, thus rendering mitochondria a significant target for novel treatment approaches. One [...]

Auhtors: Williamson T, Bai RY, Staedtke V, Huso D, Riggins GJ PMID: 27612418 PMCID: PMC5356574 DOI: 10.18632/oncotarget.11851 Abstract Inheritance of a gene mutation leads to the initiation of 5 to 10% of most cancers, including colon cancer cases. We developed a chemoprevention strategy using a novel combination of the non-steroidal anti-inflammatory (NSAID) sulindac plus the [...]

Auhtors: Fung J, Moore J Abstract The ultimate resource on intermittent fasting, the incredibly effective therapeutic approach to feeling better and losing weight that produces life-changing results. Whether you’re new to intermittent fasting or you want to fine-tune your fasting plan, this is the intermittent fasting manual to help you build the right fasting program [...]