Auhtors: Law AMK, Valdes-Mora F, Gallego-Ortega D PMID: 32121014 PMCID: PMC7140518 DOI: 10.3390/cells9030561 Abstract The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes. However, response rates from immunotherapy have been reported to be varied, with some having pronounced [...]

Auhtors: Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, et al. PMID: 32025018 PMCID: PMC7054213 DOI: 10.1038/s41586-020-1943-3 Abstract Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of [...]

Auhtors: Sala De Oyanguren FJ, Rainey NE, Moustapha A, Saric A, Sureau F, O’Connor J-E, Petit PX PMID: 32033136 PMCID: PMC7072416 DOI: 10.3390/cells9020361 Abstract Curcumin, a major active component of turmeric (Curcuma longa, L.), is known to have various effects on both healthy and cancerous tissues. In vitro studies suggest that curcumin inhibits cancer cell [...]

Auhtors: de Cabo R, Mattson MP. PMID: 31881139 DOI: 10.1056/NEJMra1905136 Abstract Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity. Keywords: intermittent fasting, health, [...]

Auhtors: Salve J, Pate S, Debnath K, Langade D PMID: 32021735 PMCID: PMC6979308 DOI: 10.7759/cureus.6466 Abstract Background Stress, anxiety and impeded sleep are a frequent feature of life in modern societies. Across socio-economic strata, stress, anxiety and ineffective sleep detract from healthful living and serve as precursors of various ailments. The use of herbs to [...]

Auhtors: Ambrosone CB, Zirpoli GR, Hutson AD, McCann WE, McCann SE, Barlow WE, et al. PMID: 31855498 PMCID: PMC7062457 DOI: 10.1200/JCO.19.01203 Abstract Purpose: Despite reported widespread use of dietary supplements during cancer treatment, few empirical data with regard to their safety or efficacy exist. Because of concerns that some supplements, particularly antioxidants, could reduce the [...]

Auhtors: Liu W, Wang W, Wang X, Xu C, Zhang N, Di W PMID: 31866467 DOI: 10.1016/j.canlet.2019.12.024 Abstract Despite the high response rate after surgery and platinum-combination chemotherapy, treatment of ovarian cancer remains challenging due to tumor recurrence and metastasis. Tumor-associated macrophages (TAMs) have been linked to cancer progression and metastasis. However, the impact of [...]

Auhtors: Campos-Carrillo A, Weitzel JN, Sahoo P, Rockne R, Mokhnatkin JV, Murtaza M, et al. PMID: 31863816 PMCID: PMC6957244 DOI: 10.1016/j.pharmthera.2019.107458 Abstract Circulating tumor DNA holds substantial promise as an early detection biomarker, particularly for cancers that do not have currently accepted screening methodologies, such as ovarian, pancreatic, and gastric cancers. Many features intrinsic to [...]

Auhtors: Fan CS, Chen LL, Hsu TA, Chen CC, Chua KV, Li CP, Huang TS PMID: 31847880 PMCID: PMC6918594 DOI: 10.1186/s13045-019-0826-2 Abstract Background: Endothelial-to-mesenchymal transition (EndoMT) can provide a source of cancer-associated fibroblasts which contribute to desmoplasia of many malignancies including pancreatic ductal adenocarcinoma (PDAC). We investigated the clinical relevance of EndoMT in PDAC, and [...]

Auhtors: Raffin C, Vo LT, Bluestone JA PMID: 31811270 PMCID: PMC7814338 DOI: 10.1038/s41577-019-0232-6 Abstract Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of Treg cells and describe new efforts in Treg cell engineering [...]