Auhtors: Fu X, Tan T, Liu P PMID: 32606952 PMCID: PMC7305821 DOI: 10.2147/CMAR.S253345 Abstract Cancer is the leading cause of death, placing a substantial global health burden. The development of the most effective treatment regimen is the unmet clinical need for cancer. Inflammation plays a role in tumorigenesis and progression, and anti-inflammation may be a [...]

Auhtors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin JP, et al. PMID: 32534647 PMCID: PMC7294238 DOI: 10.1016/S0140-6736(20)30366-4 Abstract Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 [...]

Auhtors: Babic A, Sasamoto N, Rosner BA, Tworoger SS, Jordan SJ, Risch HA, et al. PMID: 32239218 PMCID: PMC7118668 DOI: 10.1001/jamaoncol.2020.0421 Abstract Importance: Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether risk reduction extends beyond that provided by pregnancy alone or differs [...]

Auhtors: El-Benhawy SA, El-Sheredy HG, Ghanem HB, El-Soud AAA doi: https://doi.org/10.2217/bmt-2020-0007 Abstract Aim: Our objective was to investigate the effect of ionizing radiation (IR) and berberine on the expression of stem cell markers OCT4 and SOX2. Materials & methods: The study involved the following groups: Group I: MCF-7 spheroids as untreated control; Group II: MCF-7 [...]

Auhtors: Duan F, Mei C, Yang L, Zheng J, Lu H, Xia Y, et al. PMID: 32382009 PMCID: PMC7206016 DOI: 10.1038/s41598-020-64880-x Abstract Vitamin K2 has been shown to exert remarkable anticancer activity. However, the detailed mechanism remains unclear. Here, our study was the first to show that Vitamin K2 significantly promoted the glycolysis in bladder [...]

Auhtors: Han MA, Storman D, Al-Rammahy H, Tang S, Hao Q, Leung G, et al. PMID: 32226046 PMCID: PMC7105118 DOI: 10.1371/journal.pone.0230721 Abstract Background: A number of studies have reported on associations between reproductive factors, such as delivery methods, number of birth and breastfeeding, and incidence of cancer in children, but systematic reviews addressing this issue [...]

Auhtors: Cassetta L, Pollard JW PMID: 32208142 DOI: 10.1016/j.cub.2020.01.031 Abstract Cassetta and Pollard introduce tumor-associated macrophages and discuss their origin, diversity, function and plasticity. Keywords: tumor, tumor-associated macrophages Source: https://pubmed.ncbi.nlm.nih.gov/32208142/ Archive: https://archive.is/HUVcb

Auhtors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Auhtors: Yu EW, Gao L, Stastka P, Cheney MC, Soto MT, Ford CB, et al. PMID: 32150549 PMCID: PMC7062239 DOI: 10.1371/journal.pmed.1003051 Abstract Background: There is intense interest about whether modulating gut microbiota can impact systemic metabolism. We investigated the safety of weekly oral fecal microbiota transplantation (FMT) capsules from healthy lean donors and their ability [...]

Auhtors: Mirza-Aghazadeh-Attari M, Ekrami EM, Aghdas SAM, Mihanfar A, Hallaj S, Yousefi B, et al. PMID: 32135183 DOI: 10.1016/j.lfs.2020.117481 Abstract Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents and radiotherapy, and [...]