Auhtors: Liu Y, Fang S, Sun Q, Liu B PMID: 27771251 DOI: 10.1016/j.bbrc.2016.10.064 Abstract Glioblastoma is one of the most vascular brain tumour and highly resistant to current therapy. Targeting both glioblastoma cells and angiogenesis may present an effective therapeutic strategy for glioblastoma. In our work, we show that an anthelmintic drug, ivermectin, is active [...]

Auhtors: Zhang L, Xu L, Zhang F, Vlashi E PMID: 27753527 PMCID: PMC5405729 DOI: 10.1080/15384101.2016.1241929 Abstract Experimental evidence suggest that breast tumors originate from breast cancer stem cells (BCSCs), and that mitochondrial biogenesis is essential for the anchorage-independent clonal expansion and survival of CSCs, thus rendering mitochondria a significant target for novel treatment approaches. One [...]

Auhtors: Williamson T, Bai RY, Staedtke V, Huso D, Riggins GJ PMID: 27612418 PMCID: PMC5356574 DOI: 10.18632/oncotarget.11851 Abstract Inheritance of a gene mutation leads to the initiation of 5 to 10% of most cancers, including colon cancer cases. We developed a chemoprevention strategy using a novel combination of the non-steroidal anti-inflammatory (NSAID) sulindac plus the [...]

Authors: Fung J, Moore J Abstract Thousands of books have been written about the latest and greatest diets that will help people lose weight and improve health. But a key element in any successful nutritional health program is a tried-and-true method that most people haven’t thought about—yet it could be revolutionary for taking health to [...]

Auhtors: Fung J, Moore J Abstract The ultimate resource on intermittent fasting, the incredibly effective therapeutic approach to feeling better and losing weight that produces life-changing results. Whether you’re new to intermittent fasting or you want to fine-tune your fasting plan, this is the intermittent fasting manual to help you build the right fasting program [...]

Authors: Zhang P, Tsuchiya K, Kinoshita T, Kushiyama H, Suidasari S, Hatakeyama M. PMID: 27733681 PMCID: PMC5114405 DOI: 10.1074/jbc.M116.743815 Abstract Vitamin B6 includes six water-soluble vitamers: pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), and their phosphorylated forms. Pyridoxal 5'-phosphate (PLP) is an important cofactor for many metabolic enzymes. Several lines of evidence demonstrate that blood levels [...]

Authors: Kim JK, Park SU PMID: 28096787 PMCID: PMC522573 doi: 10.17179/excli2016-485 Abstract Sulforaphane [SFN: 1-isothiocyanato-4-(methylsulfinyl)butane] belongs to the isothiocyanate class of phytochemicals. Glucoraphanin, a glucosinolate precursor of SFN, is a glucosinolate found in cruciferous vegetables such as broccoli, cabbage, cauliflower, and kale. All glucosinolates are composed of a basic structure consisting of a β-D-thioglucose group, [...]

Authors:Teng F, He T, Huang S, Bo CP, Li Z, Chang JL. PMID: PMC5113089 DOI: 10.1038/ijos.2016.18 Abstract Oral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride (CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a double-blinded, randomised controlled trial of 91 subjects, [...]

Authors: Ornaghi S, Davis JN, Gorres KL, Miller G, Paidas MJ PMID: 27657833 PMCID: PMC5102808 DOI: 10.1016/j.virol.2016.09.012 Abstract Cytomegalovirus (CMV) infection can generate debilitating disease in immunocompromised individuals and neonates. It is also the most common infectious cause of congenital birth defects in infected fetuses. Available anti-CMV drugs are partially effective but are limited by [...]

Auhtors: Zhan T, Rindtorff N, Boutros M PMID: 27617575 PMCID: PMC5357762 DOI: 10.1038/onc.2016.304 Abstract Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed [...]