Auhtors: Baracos VE, Martin L, Korc M, Guttridge DC, Fearon KCH PMID: 29345251 DOI: 10.1038/nrdp.2017.105 Abstract Cancer-associated cachexia is a disorder characterized by loss of body weight with specific losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination of reduced food intake and metabolic changes, including elevated energy expenditure, excess [...]

Ivermectin is a pivotal drug for the control of onchocerciasis and lymphatic filariasis, which is increasingly identified as a useful drug for the control of other Neglected Tropical Diseases.

Authors: Sanna A, Firinu D, Zavattari P, Valera P PMID: 29324654 PMCID: PMC5793296 DOI: 10.3390/nu10010068 Abstract Zinc is an essential trace element for living organisms and their biological processes. Zinc plays a key role in more than 300 enzymes and it is involved in cell communication, proliferation, differentiation and survival. Zinc plays also a role [...]

Auhtors: Siddiqui FJ, Assam PN, de Souza NN, Sultana R, Dalan r, Chan ES PMID: 29756472 PMCID: PMC5954571 DOI: 10.1177/2156587217753004 Abstract Background: Renewed interest in vinegar as a glucose-lowering agent led to several small trials in the recent past. However, none of the trials could independently provide sufficient evidence. Objectives: Our review aimed to obtain [...]

Authors: Torrealba JR, Fisher S, Kanne JP, Butt YM, Glazer C, Kershaw C PMID: 29122655 DOI: 10.1016/j.humpath.2017.10.028 Abstract Organizing pneumonia (OP) is a common pattern of lung injury that can be associated with a wide range of etiologies. Typical and not-so-typical imaging features of OP occur, as both common and rare lung pathologies can mimic [...]

Auhtors: Yu C, Li W-b, Liu J-b, Lu J-w, Feng J-f PMID: 29282893 PMCID: PMC5806108 DOI: 10.1002/cam4.1287 Abstract In eukaryotic cells, autophagy is a process associated with programmed cell death. During this process, cytoplasmic proteins and organelles are engulfed by double-membrane autophagosomes, which then fuse with lysosomes to form autolysosomes. These autolysosomes then degrade their [...]

Authors: Keihanian F, Saeidinia A, Bagheri RK, Johnston TP, Sahebkar A PMID: 29052850 DOI: 10.1002/jcp.26249 Abstract Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help [...]

Auhtors: Oberoi S, Robinson PD, Cataudella D, Culos-Reed SN, Davis H, Duong N, et al. PMID: 29458789 DOI: 10.1016/j.critrevonc.2017.12.011 Abstract Purpose: Objective was to determine whether physical activity reduces the severity of fatigue in patients with cancer or hematopoietic stem cell transplant (HSCT) recipients. Methods: We conducted a meta-analysis of randomized trials comparing physical activity [...]

Auhtors: Augustin K, Khabbush A, Williams S, Eaton S, Orford M, Cross JH, et al. PMID: 29263011 DOI: 10.1016/S1474-4422(17)30408-8 Abstract High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-pharmacological treatment for refractory epilepsy. A key mechanism of this treatment is thought to be the generation of ketones, which provide brain cells [...]

Auhtors: Dominguez-Gomez G, Chavez-Blanco A, Medina-Franco JL, Saldivar-Gonzalez F, Flores-Torrontegui Y, Juarez M, et al. PMID: 29257278 DOI: 10.3892/mmr.2017.8231 Abstract The aim of the present study was to demonstrate that ivermectin preferentially inhibited cancer stem‑like cells (CSC) in breast cancer cells and downregulated the expression of 'stemness' genes. Computational searching of DrugBank, a database of [...]