Auhtors: Mørch LS, Skovlund CW, Hannaford PC, Iversen L, Fielding S, Lidegaard Ø PMID: 29211679 DOI: 10.1056/NEJMoa1700732 Abstract Background: Little is known about whether contemporary hormonal contraception is associated with an increased risk of breast cancer. Methods: We assessed associations between the use of hormonal contraception and the risk of invasive breast cancer in a [...]

Auhtors: Na RS, Ma C, Liu QR, Wu LM, Zheng XL, Liu ZW PMID: 29434820 PMCID: PMC5776524 DOI: 10.3892/etm.2017.5602 Abstract The primarily metabolic abnormality in type 2 diabetes mellitus (T2DM) is the defect in gluconeogenesis and glucose uptake. Itraconazole (ITCZ) is a traditional azole drug with anti-fungal and anticancer properties. However, limited attention has been [...]

Auhtors: Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, et al. PMID: 29194365 PMCID: PMC5751192 DOI: 10.3390/ijms18122589 Abstract Abstract: Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, including preclinical, clinical, and epidemiological studies, [...]

Auhtors: Kitano Y, Okabe H, Yamashita YI, Nakagawa S, Saito Y, Umezaki N, et al. PMID: 29123259 PMCID: PMC5785749 DOI: 10.1038/bjc.2017.401 Abstract Background: Inflammation and immune characteristics of the tumour microenvironment have therapeutic significance. The aim of this study was to investigate the clinical impact on disease progression in human extrahepatic cholangiocarcinoma (ECC). Methods: A [...]

Auhtors: Maruvada P, Leone V, Kaplan LM, Chang EB PMID: 29120742 DOI: 10.1016/j.chom.2017.10.005 Abstract Mounting evidence indicates that the gut microbiome responds to diet, antibiotics, and other external stimuli with speed and high precision and in ways that impact a variety of metabolic conditions including obesity and non-alcoholic fatty liver disease. Despite a decade of [...]

Authors: Liu S, Sheng J, Li B, Zhang X doi: https://doi.org/10.3389/fnhum.2017.00526 Abstract Non-invasive brain stimulation (NBS) is a promising treatment for major depressive disorder (MDD), which is an affective processing disorder involving abnormal emotional processing. Many studies have shown that repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) over the prefrontal cortex [...]

Auhtors: Liu S, Chen S, Zeng J PMID: 29115550 DOI: 10.3892/mmr.2017.7970 Abstract Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor‑β (TGF‑β) [...]

Auhtors: Sobotka T PMID: 29160188 DOI: 10.1017/S0021932017000323 Abstract This study discusses fertility trends and variation in countries that completed the transition from high to around-replacement fertility in the 1950s to 1980s, especially in Europe, East Asia and North America, and summarizes the key relevant findings for those countries with a more recent experience of fertility [...]

Auhtors: Wang N, Tian X, Chen Y, Tan HQ, Xie PJ, Chen SJ, et al. PMID: 29089617 PMCID: PMC5666019 DOI: 10.1038/s41598-017-14408-7 Abstract The aim of this study was to determine whether low dose doxycycline as an anti-inflammatory agent could improve glucose metabolism in diabetic animals. Therefore, doxycycline was supplemented in drinking water to 6-week-old male [...]

Auhtors: Majety M, Runza V, Lehmann C, Hoves S, Ries CH PMID: 28941174 DOI: 10.1111/febs.14277 Abstract Despite decades of research, cancer remains a devastating disease and new treatment options are needed. Today cancer is acknowledged as a multifactorial disease not only comprising of aberrant tumor cells but also the associated stroma including tumor vasculature, fibrotic [...]