Authors: Wu D, Yang XO PMID: 32205092 PMCID: PMC7156211 DOI: 10.1016/j.jmii.2020.03.005 Abstract COVID-19 emerges as a pandemic disease with high mortality. Development of effective prevention and treatment is an urgent need. We reviewed TH17 responses in patients with SARS-CoV-2 and proposed an FDA approved JAK2 inhibitor Fedratinib for reducing mortality of patients with TH17 type [...]

Authors: Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z PMID: 32171076 PMCID: PMC7270627 DOI: 10.1016/S0140-6736(20)30566-3 Abstract Background: Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients [...]

Auhtors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Auhtors: Yu EW, Gao L, Stastka P, Cheney MC, Soto MT, Ford CB, et al. PMID: 32150549 PMCID: PMC7062239 DOI: 10.1371/journal.pmed.1003051 Abstract Background: There is intense interest about whether modulating gut microbiota can impact systemic metabolism. We investigated the safety of weekly oral fecal microbiota transplantation (FMT) capsules from healthy lean donors and their ability [...]

Authors: Yang SN, Atkinson SC, Wang C, Lee A PMID: 32135219 DOI: 10.1016/j.antiviral.2020.104760 Abstract Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and dengue virus (DENV) represent a major burden for human health worldwide. Although RNA viruses replicate in the infected host cell cytoplasm, the nucleus is central to key stages of [...]

Auhtors: Mirza-Aghazadeh-Attari M, Ekrami EM, Aghdas SAM, Mihanfar A, Hallaj S, Yousefi B, et al. PMID: 32135183 DOI: 10.1016/j.lfs.2020.117481 Abstract Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents and radiotherapy, and [...]

Authors: Teng M, Zhao YJ, Khoo AL, Yeo TC, Yong QW, Lim BP PMID: 31769848 DOI: 10.1093/nutrit/nuz074 Abstract Context: Coconut oil is rich in medium-chain fatty acids and has been claimed to have numerous health benefits. Objective: This review aimed to examine the evidence surrounding coconut oil consumption and its impact on cardiovascular health. Data [...]

Authors: Li K, Wu J, Wu F, Guo D, Cen L, Fang Z et al. PMID: 32118615 PMCID: PMC7147273 DOI: 10.1097/RLI.0000000000000672 Abstract Objective: The aim of this study was to investigate the clinical and computed tomography (CT) features associated with severe and critical coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods: Eighty-three patients with COVID-19 [...]

Authors: Kanne JP, Little BP, Chung JH, Elicker BM PMID: 32105562 PMCID: PMC7233379 DOI: 10.1148/radiol.2020200527 Abstract Infections by COVID-19 continue to increase in China and worldwide. The betacoronavirus was first reported in December 2019 in Wuhan, China. As of February 24, 2020, the World Health Organization (WHO) reports 78,811 laboratory-confirmed cases, including more than 2200 [...]

Auhtors: Law AMK, Valdes-Mora F, Gallego-Ortega D PMID: 32121014 PMCID: PMC7140518 DOI: 10.3390/cells9030561 Abstract The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes. However, response rates from immunotherapy have been reported to be varied, with some having pronounced [...]