Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity rates.

Authors:Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. PMID: PMC7498100 DOI: 10.1371/journal.pone.0239252 Abstract Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory [...]

Authors: Luks AM, Swenson ER PMID: 32521167 PMCID: PMC7462317 DOI: 10.1513/AnnalsATS.202005-418FR Abstract During the ongoing coronavirus disease (COVID-19) pandemic, reports in social media and the lay press indicate that a subset of patients are presenting with severe hypoxemia in the absence of dyspnea, a problem unofficially referred to as "silent hypoxemia." To decrease the risk [...]

Authors:Burton MJ, Clarkson JE, Goulao B, Glenny AM, McBain AJ, Schilder AG. PMID:PMC8188293 DOI: 10.1002/14651858.CD013628.pub2 Abstract Background: COVID-19 infection poses a serious risk to patients and - due to its contagious nature - to those healthcare workers (HCWs) treating them. The risks of transmission of infection are greater when a patient is undergoing an aerosol-generating [...]

Authors: Jans DA, Wagstaff KM PMID: 32942671 PMCID: PMC7564151 DOI: 10.3390/cells9092100 Abstract The small molecule macrocyclic lactone ivermectin, approved by the US Food and Drug Administration for parasitic infections, has received renewed attention in the last eight years due to its apparent exciting potential as an antiviral. It was identified in a high-throughput chemical screen [...]

Authors: Zimering MB, Razzaki T, Tsang T, Shin JJ PMID: 33117497 PMCID: PMC7590925 Abstract Advanced age and medical co-morbidity are strong predictors of mortality in COVID-19 infection. Yet few studies (to date) have specifically addressed risk factors associated with COVID-19 mortality in a high-risk subgroup of older US adults having one or more chronic diseases. [...]

Authors:Meister TL, Briggemann Y, Todt D, Muller JA, Grob R. PMID: PMC7454736 DOI: 10.1093/infdis/jiaa471 Abstract The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic creates a significant threat to global health. Recent studies suggested the significance of throat and salivary glands as major sites of virus replication and transmission during early coronavirus disease 2019, [...]

Authors: Somi VK, Mehta A, Ratre YK, Tiwari AK, Amit A. PMID: PMC7832734 DOI: 10.1016/j.ejphar.2020.173551 Abstract The severity of the recent pandemic and the absence of any specific medication impelled the identification of existing drugs with potential in the treatment of Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Curcumin, known for its [...]

Authors: Salton F, Confalonieri P, Santus P, Harari S, Scala R, Lanini S et al. PMID: 33072814 PMCID: PMC7543560 DOI: 10.1093/ofid/ofaa421 Abstract Background: In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality. Severe dysregulated systemic inflammation is the [...]

Authors: Han AY, Mukdad L, Long JL, Lopez IA PMID: 32914699 PMCID: PMC7488171 DOI: 10.1177/1073858420956905 Abstract In recent months it has emerged that the novel coronavirus-responsible for the COVID-19 pandemic-causes reduction of smell and taste in a large fraction of patients. The chemosensory deficits are often the earliest, and sometimes the only signs in otherwise [...]