In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality.

Respiratory distress requiring intubation is the most serious complication associated with coronavirus disease 2019 (COVID-19).

Authors:Annweiler C, Hanotte B, de L'Eprevier CG, Sabatier JM, Lafaie L. PMID:PMC7553119 doi: 10.1016/j.jsbmb.2020.105771 Abstract Vitamin D may be a central biological determinant of COVID-19 outcomes. The objective of this quasi-experimental study was to determine whether bolus vitamin D3 supplementation taken during or just before COVID-19 was effective in improving survival among frail elderly nursing-home [...]

Authors: Magro CM, Mulvey JJ, Laurence J, seshan S, Crowson AN, Harp J PMID: 33058948 PMCID: PMC7550120 DOI: 10.1016/j.humpath.2020.10.002 Abstract The purpose of this study was to examine the deltoid skin biopsy in twenty-three patients with coronavirus disease 2019 (COVID-19), most severely ill, for vascular complement deposition and correlate this with severe acute respiratory syndrome [...]

Authors: Islam MN, Hossain KS, Sarker PP, Ferdous J, Hannan A, Rahman M. PMID: PMC7675410 DOI: 10.1002/ptr.6895 Abstract Nigella sativa seed and its active compounds have been historically recognized as an effective herbal panacea that can establish a balanced inflammatory response by suppressing chronic inflammation and promoting healthy immune response. The essential oil and other [...]

Authors: Yeramaneni S, Doshi P, Sands K, Cooper M, Kurbegov D, Fromell G PMID: 33058865 PMCID: PMC7550093 doi: 10.1053/j.gastro.2020.10.011 Abstract Previous reports have found that in-hospital famotidine use in coronavirus disease 2019 (COVID-19) patients was associated with reduced risk of death or intubation.1 , 2 In 1 of these studies the authors proposed that famotidine [...]

Authors: Villa G, Romagnoli S, De Rosa S, Greco M, Resta M PMID: 33046113 PMCID: PMC7549343 DOI: 10.1186/s13054-020-03322-6 Abstract Background: Systemic inflammation in COVID-19 often leads to multiple organ failure, including acute kidney injury (AKI). Renal replacement therapy (RRT) in combination with sequential extracorporeal blood purification therapies (EBP) might support renal function, attenuate systemic inflammation, [...]

Authors: Sanabria-Mazo JP, Montero-Marin J, Feliu-Soler A, Gasion V, Navarro-Gil M PMID: 33050630 PMCID: PMC7599726 DOI: 10.3390/jcm9103246 Abstract The lack of highly effective treatments for fibromyalgia (FM) represents a great challenge for public health. The objective of this parallel, pilot randomized controlled trial (RCT) was two-fold: (1) to analyze the clinical effects of mindfulness plus [...]

Authors: Mather JF, Seip RL, McKay RG PMID: 32852338 PMCID: PMC7473796 DOI: 10.14309/ajg.0000000000000832 Abstract Introduction: To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine. Methods: Retrospective, propensity-matched observational study of consecutive COVID-19-positive patients between February 24, 2020, and May 13, 2020. Results: Of 878 patients in the [...]

Authors: Chamie J Abstract In these eight Peruvian State analyses, Ivermectin distributions preceded sound reductions in excess deaths and case fatality rate (CFR). The variation in the number of detected cases nor the vulnerable population decrease can explain this reduction. Other possible explanations, such as cross-immunity with dengue, or mere causality, have been discarded due [...]