Authors: Wu Y, Cheng X, Jiang G, Tang H, Ming S. PMID: 34911943 PMCID: PMC8672330 DOI: 10.1038/s41522-021-00262-z Abstract The human oral and gut commensal microbes play vital roles in the development and maintenance of immune homeostasis, while its association with susceptibility and severity of SARS-CoV-2 infection is barely understood. In this study, we investigated the [...]

Authors: McCoy J, Goren A, Cadegiani FA, Vano-Galvan S, Kovacevic M, Situm M et al. PMID: 34350193 PMCID: PMC8326462 DOI: 10.3389/fmed.2021.668698 Abstract Antiandrogens have demonstrated a protective effect for COVOD-19 patients in observational and interventional studies. The goal of this study was to determine if proxalutamide, an androgen receptor antagonist, could [...]

Auhtors: Komohara Y, Niino D, Ohnishi K, Ohshima K, Takeya M PMID: 34298810 PMCID: PMC8304632 DOI: 10.3390/cancers13143597 Abstract The tumor microenvironment includes dendritic cells, T-cytotoxic, T-helper, reactive B-lymphoid cells and macrophages; these reactive cells could interplay with malignant cells and promote tumor growth and survival. Among its cellular components, tumor-associated macrophages (TAM) represent a component [...]

Authors:Cozier YC, Castro-Webb N, Hochberg NS, Rosenberg L, Albert MA, Palmer JR. PMID: PMC8315514 DOI: 10.1371/journal.pone.0255132 Abstract Objective: Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection. Black women commonly experience 25(OH)D insufficiency and are overrepresented among COVID-19 cases. We conducted a prospective [...]

Authors: Perrella F, Coppola F, Petrone A, Platells C, Montesarchio D, Ravagnan G PMID: 34356672 PMCID: PMC8301781 DOI: 10.3390/biom11071048 Abstract In the search for new therapeutic strategies to contrast SARS-CoV-2, we here studied the interaction of polydatin (PD) and resveratrol (RESV)-two natural stilbene polyphenols with manifold, well known biological activities-with Spike, the viral protein essential [...]

Authors: Zhao J, Yang Y, Huang H, Li D, Gu D PMID: 32750119 PMCID: PMC7454371 DOI: 10.1093/cid/ciaa1150 Abstract To explore any relationship between the ABO blood group and the coronavirus disease 2019 (COVID-19) susceptibility, we compared ABO blood group distributions in 2173 COVID-19 patients with local control populations, and found that blood group A was [...]

Auhtors: Lee KA, Luong MK, Shaw H, Nathan P, Bataille V, Spector TD Abstract The gut microbiome (GM) has been implicated in a vast number of human pathologies and has become a focus of oncology research over the past 5 years. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug [...]

Auhtors: Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, et al. PMID: 34256014 PMCID: PMC9020749 DOI: 10.1016/j.cell.2021.06.019 Abstract Diet modulates the gut microbiome, which in turn can impact the immune system. Here, we determined how two microbiota-targeted dietary interventions, plant-based fiber and fermented foods, influence the human microbiome and immune system [...]

Authors: Tomassa-Irriguible TM, Lielsa-Berrocal L PMID: 34243781 PMCID: PMC8269403 DOI: 10.1186/s12937-021-00727-z Abstract There are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the [...]

The first local transmission of the SARS-CoV-2 Delta variant in mainland China ... suggesting potentially faster viral replication and greater infectiousness of Delta during early infection