Authors: Cadegiani FA, Goren A, Wambier CG, McCoy J PMID: 34249367 PMCID: PMC8262389 DOI: 10.1016/j.nmni.2021.100915 Abstract In a prospective observational study (pre-AndroCoV Trial), the use of nitazoxanide, ivermectin and hydroxychloroquine demonstrated unexpected improvements in COVID-19 outcomes when compared to untreated patients. The apparent yet likely positive results raised ethical concerns on the employment of further [...]

Authors: Hill A, Garratt A, Levi J, Falconer J, Ellis L, McCann K et al. PMID: 34796244 PMCID: PMC8420640 DOI: 10.1093/ofid/ofab358 Abstract Ivermectin is an antiparasitic drug being investigated for repurposing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ivermectin showed in vitro activity against SARS-COV-2, but only at high concentrations. This meta-analysis investigated ivermectin [...]

Authors: Ohl ME, Miller DR, Lund BC, Kobayashi T, Miell KR PMID: 34264329 PMCID: PMC8283561 DOI: 10.1001/jamanetworkopen.2021.14741 Abstract Importance: Randomized clinical trials have yielded conflicting results about the effects of remdesivir therapy on survival and length of hospital stay among people with COVID-19. Objective: To examine associations between remdesivir treatment and survival and length of [...]

Authors: Zhou L, Shin S Abstract Small fiber neuropathy (SFN) is common and can be associated with many medical conditions, including reports of an association with COVID-19. A Dutch study suggests a prevalence of 52.95 per 100,000 population that increases with age.1 Standardized diagnostic criteria for SFN are not fully established and skin biopsy [...]

Authors: Al Sulaiman K, Aljuhani O, Al Dossari M, Alshahrani A, Alharbi A PMID: 34193235 PMCID: PMC8242279 DOI: 10.1186/s13054-021-03648-9 Abstract Background: Thiamine is a precursor of the essential coenzyme thiamine pyrophosphate required for glucose metabolism; it improves the immune system function and has shown to reduce the risk of several diseases. The role of thiamine [...]

Authors: Assimakopoulos SF, Aretha D, Kominos D, Dimitropoulou D, Lagadinou M PMID: 34182881 DOI: 10.1080/23744235.2021.1945675 Abstract Background: N-acetyl-cysteine (NAC) has been previously shown to exert beneficial effects in diverse respiratory diseases, through antioxidant and anti-inflammatory actions. Our aim was to evaluate NAC potential impact in hospitalised patients with COVID-19 pneumonia, in [...]

Authors: Altay O, Arif M, Li X, Yang H, Aydin M, Alkurt G PMID: 34180141 PMCID: PMC8420376 DOI: 10.1002/advs.202101222 Abstract COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD+ ) and glutathione metabolism. Here it is investigated if administration of a mixture of combined metabolic activators (CMAs) [...]

Authors: Patterson BK, Guevara-Coto J, Yogendra R, Francisco E, Long E, Pise A PMID: 34262570 PMCID: PMC8273732 DOI: 10.3389/fimmu.2021.700782 Abstract Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being investigated. Here, we explored the role of CCR5 and its ligands [...]

After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials.

Authors: Blum VF, Cimerman S, Huneter JR, Tierno P, Lacerda A, Soeiro A PMID: 34222847 PMCID: PMC8235996 DOI: 10.1016/j.eclinm.2021.100981 Abstract Background: The absence of specific antivirals to treat COVID-19 leads to the repositioning of candidates' drugs. Nitazoxanide (NTZ) has a broad antiviral effect. Methods: This was a randomized, double-blind pilot clinical trial comparing NTZ 600 [...]