Auhtors: Welsh J, Bak MJ, Narvaez CJ PMID: 36028390 PMCID: PMC9509427 DOI: 10.1016/j.molmed.2022.07.002 Abstract Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-translational γ-carboxylation of a small number of proteins, including clotting factors. These modified proteins have now been implicated in diverse physiological and pathological processes including cancer. Vitamin K intake has [...]

Authors: Oliaei S, Mehrtak M, Karimi A, Noori T, Shojaei A, Dadras O PMID: 34412709 PMCID: PMC8374420 DOI: 10.1186/s40001-021-00570-2 Abstract Background: Oxygenation serves as a cornerstone in the treatment of COVID-19, and several methods have been extensively studied so far. Herein, we aimed to systematically review the studies discussing hyperbaric oxygen therapy (HBOT) to examine [...]

Authors: Verma AK, Lavine KJ, Lin CY PMID: 34407340 PMCID: PMC8385564 DOI: 10.1056/NEJMc2109975 Abstract The Centers for Disease Control and Prevention recently reported cases of myocarditis and pericarditis in the United States after coronavirus disease 2019 (Covid-19) messenger RNA (mRNA) vaccination.1 In recently published reports, diagnosis of myocarditis was made with the use of noninvasive [...]

Auhtors: Bower JE, Partridge AH, Wolff AC, Thorner ED, Irwin MR, Joffe H, et al. PMID: 34406839 PMCID: PMC8547916 DOI: 10.1200/JCO.21.00279 Abstract Purpose: Younger women are at risk for depression and related symptoms following breast cancer. The Pathways to Wellness study, a randomized, multi-institution, three-arm trial, tested the efficacy of two behavioral interventions for younger [...]

Auhtors: Carlberg C, Velleuer E PMID: 34411566 DOI: 10.1016/j.bcp.2021.114735 Abstract Uncontrolled overgrowth of cells, such as in cancer, is an unavoidable risk in life that affects nearly every second individual in industrialized countries. However, in part this risk can be controlled through lifestyle adjustments, such as the avoidance of smoking, unhealthy diet, obesity, physical inactivity [...]

Auhtors: Wang Y, Lu X, Wang X, Qiu Q, Zhu P, Ma L, et al. PMID: 34384247 PMCID: PMC8484060 DOI: 10.1161/CIRCRESAHA.121.319104 Abstract Rationale: Anthracycline-induced cardiotoxicity (AIC) is a major side effect that limits the use of anthracyclines as effective chemotherapeutics. No mechanism-based therapy is available when cardiac function deteriorates. Objective: We aim to elucidate the [...]

Authors: Kabinger F, Stiller C, Schmitzova J, Kokic G PMID: 34381216 PMCID: PMC8437801 DOI: 10.1038/s41594-021-00651-0 Abstract Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in humans. Here, [...]

Treatment for coronavirus disease 2019 (COVID19) pneumonia remains empirical and the search for therapies that can improve outcomes continues. Melatonin has been shown to have anti-inflammatory, antioxidant, and immune-modulating effects that may address key pathophysiologic mechanisms in the development and progression of acute respiratory distress syndrome (ARDS), which has been implicated as the likely cause of death in COVID19. We aimed to describe the observable clinical outcomes and tolerability of high-dose melatonin (hdM) given as adjuvant therapy in patients admitted with COVID19 pneumonia.

Authors: Yu LM, Bafadhel M, Doeward J, Hayward G PMID: 34388395 PMCID: PMC8354567 DOI: 10.1016/S0140-6736(21)01744-X Abstract Background: A previous efficacy trial found benefit from inhaled budesonide for COVID-19 in patients not admitted to hospital, but effectiveness in high-risk individuals is unknown. We aimed to establish whether inhaled budesonide reduces time to recovery and COVID-19-related hospital [...]

Auhtors: Nishikawa H, Goto M, Fukunishi S, Asai A, Nishiguchi S, Higuchi K PMID: 34445197 PMCID: PMC8395185 DOI: 10.3390/ijms22168491 Abstract The term "cachexia" is derived from the Greek words kakos (bad) and hexis (habit). Cachexia is a malnutrition associated with chronic diseases such as cancer, chronic heart failure, chronic renal failure, and autoimmune diseases, and [...]