Auhtors: Welsh J, Bak MJ, Narvaez CJ
PMID: 36028390 PMCID: PMC9509427 DOI: 10.1016/j.molmed.2022.07.002
Abstract
Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-translational γ-carboxylation of a small number of proteins, including clotting factors. These modified proteins have now been implicated in diverse physiological and pathological processes including cancer. Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Newly discovered functions of vitamin K in cancer cells include activation of the steroid and xenobiotic receptor (SXR) and regulation of oxidative stress, apoptosis, and autophagy. We provide an update of vitamin K biology, non-canonical mechanisms of vitamin K actions, the potential functions of vitamin K-dependent proteins in cancer, and observational trials on vitamin K intake and cancer.
Keywords: Gla proteins; cancer; menaquinone; phylloquinone; vitamin K
Source: https://pubmed.ncbi.nlm.nih.gov/36028390/
Archive: https://archive.is/utPFY
