Authors: Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Liu J PMID: 34478478 PMCID: PMC8415618 DOI: 10.1371/journal.pone.0257016 Abstract Background: Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) but the mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of [...]

Authors: Marconi VC, Ramanan AV, de Bono S, Kartman CE, Krishnan V PMID: 34480861 PMCID: PMC8409066 DOI: 10.1016/S2213-2600(21)00331-3 Abstract Background: Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory properties. This study evaluates the efficacy and safety of baricitinib in combination with standard of care for the treatment of hospitalised adults with [...]

Authors: Chen BM, Cheng TL, Roffler SR PMID: 34469112 DOI: 10.1021/acsnano.1c05922 Abstract Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance, block antibody and protein binding sites, and enhance the half-life and efficacy of therapeutic molecules. Some naïve individuals [...]

Authors: McLelland J Abstract In this revised second edition, the author includes her ferroptosis protocol, an anticancer weapon using old drugs, a special diet, exercise and supplements. As in the original edition of this book, the author elaborates on her own struggle with cancer and relates the discoveries she made along the way. The book [...]

Auhtors: Farvid MS, Sidahmed E, Spence ND, Mante AK, Rosner BA, Barnett JB PMID: 34455534 DOI: 10.1007/s10654-021-00741-9 Abstract Red meat and processed meat consumption has been hypothesized to increase risk of cancer, but the evidence is inconsistent. We performed a systematic review and meta-analysis of prospective studies to summarize the evidence of associations between consumption [...]

Authors: Morgenstern J, Redondo JN, Olavarria A, Rondon I, Roca S, De Leon A et al. PMID: PMC8405705 DOI: 10.7759/cureus.17455 Abstract Background: Ivermectin is a drug that has been shown to be active against coronavirus disease 19 (COVID-19) in previous studies. Healthcare personnel are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. [...]

Ivermectin is a drug that has been shown to be active against coronavirus disease 19 (COVID-19) in previous studies. Healthcare personnel are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Therefore, we decided to offer them ivermectin as a pre-exposure prophylaxis (PrEP) method.

Auhtors: Abbasi F, Lamendola C, Harris CS, Harris V, Tsai M-S, Tripathi P, et al. PMID: 34433298 PMCID: PMC8551023 DOI: 10.1161/ATVBAHA.121.316159 Abstract Objective: Statin treatment reduces the risk of atherosclerotic cardiovascular disease but is associated with a modest increased risk of type 2 diabetes, especially in those with insulin resistance or prediabetes. Our objective was [...]

Authors: Dacasin AB, Diagono DM, So PK, Bautista VR, Bucu ML, Bueno PR DOI: 10.22271/phyto.2021.v10.i6a.14254 Abstract This review summarizes the background of Cocos nucifera, the benefits of the isolated virgin coconut oil (VCO), such as its potential as an adjunctive treatment for COVID-19, and its pharmacological effects, including antiviral and anti-inflammatory properties that could be [...]

Auhtors: Qin W-M, Wang K, Huang J-R, Mei X-L, Zhi Z doi: https://doi.org/10.6000/1929- Abstract Phosphodiesterase is an enzyme that degrades the phosphodiester bond in the second messenger molecules cAMP and cGMP, and regulates the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. Sildenafil is a potent and selective inhibitor of the type [...]