Authors: Lawton JM, Conway LT, Crosson JT, Smith CL, Abraham PA PMID: 3994472 Abstract A single 45-g dose of intravenous ascorbic acid, a metabolic precursor of oxalate, was administered to a patient as adjuvant therapy for primary amyloidosis and the nephrotic syndrome. Acute oliguric renal failure occurred. Postmortem histopathologic examination of renal tissue revealed extensive [...]

Auhtors: Dawson M, Watson TR PMID: 3978024 PMCID: PMC1463790 DOI: 10.1111/j.1365-2125.1985.tb02617.x Abstract Four different dose forms of mebendazole were administered to human volunteers, and urine was collected and assayed for mebendazole and unconjugated metabolites of mebendazole. Oral administration of mebendazole as an oily suspension slightly enhances the bioavailability of the drug, however mebendazole is not [...]

Authors: Almqvist P, Skudder P, Kuenzig M, Schwartz SI PMID: 6476613 Abstract The adult respiratory distress syndrome (ARDS) seen in endotoxin shock is accompanied by the release of beta-endorphin. The hypotension that is seen in endotoxin shock can also be produced by injection of beta-endorphin and is effectively blocked by the use of antiserotonin drugs. [...]

Authors: McGoon MD, Vanhoutte PM PMID: 6470141 PMCID: PMC425237 DOI: 10.1172/JCI111499 Abstract To examine the effect of platelets and 5-hydroxytryptamine on pulmonary arterial smooth muscle, rings of canine pulmonary arteries, with and without endothelium, were studied under isometric conditions in physiological salt solution. 5-Hydroxytryptamine, but not the thromboxane-like endoperoxide analogue U-46619, produced concentration-dependent contractions of [...]

To compare the penetrability of methylprednisolone into lung tissue with that of prednisone, blood and bronchoalveolar lavage (BAL) fluid levels of methylprednisolone and prednisone were measured in 17 patients with a variety of lung diseases.

Auhtors: Howell AN, Sagar R PMID: 276880 PMCID: PMC392552 DOI: 10.1073/pnas.75.5.2358 Abstract The effect of cytoplasm upon the expression of tumorigenicity was examined with a pair of mouse and a pair of Chinese hamster cell lines, in intraspecies cybrids formed by reciprocal fusions between either tumorigenic or nontumorigenic cells and cytoplasms derived from them. With [...]

Auhtors: Halma MT, Tuszynski J, Marik P PMID: 198801 PMCID: PMC431708 DOI: 10.1073/pnas.74.9.3735 Abstract A tumorigenic anchorage-dependent cell line (H-91) was established in culture from an azo-dye-induced rat ascites hepatoma. When grown in a glucose-containing medium the cells exhibit high rates of lactic acid production characteristic of rapidly growing tumor cells. However, when glucose is [...]

Auhtors: Szent-Gyorgyi A PMID: 268635 PMCID: PMC431314 DOI: 10.1073/pnas.74.7.2844 Abstract Complex living structures developed on our globe after the appearance of light and oxygen. In functions of these structures, solid state phenomena play a major role. The structural proteins were made into radicals by doping, the covalent incorporation of electron acceptors. This lent mobility to [...]

Auhtors: MacMahon B, Cole PE, Lin TM, Lowe CR, Mirra AP PMID: 5312521 PMCID: PMC2427645 Abstract An international collaborative study of breast cancer and reproductive experience has been carried out in 7 areas of the world. In all areas studied, a striking relation between age at first birth and breast cancer risk was observed. It [...]

Auhtors: Dayton S, Pearce ML, Hashimoto S, Fakler LJ, Hiscock E, Dixon WJ PMID: 13884081 DOI: 10.1056/NEJM196205172662001 Abstract This report describes a clinical trial, with domiciled male veterans, designed to determine whether a diet which lowers serum cholesterol concentration can prevent overt complications of coronary heart disease and other manifestations of atherosclerosis. Volunteers were allocated [...]