Authors: Salem M, Kasinski N, Munoz R, Chernow B PMID: 8001362 DOI: 10.1097/00003246-199501000-00019 Abstract Objectives: To study the effects of endotoxin on magnesium homeostasis; to determine if progressive magnesium deficiency alters outcome from endotoxin challenge; and to evaluate the efficacy of magnesium therapy in reducing endotoxin-induced mortality. Design: Prospective, placebo-controlled, randomized, multiexperiment studies. Setting: Research [...]

Auhtors: Tsukada M, Ohsumi Y PMID: 8224160 DOI: 10.1016/0014-5793(93)80398-e Abstract Autophagy in the yeast is similar to that in mammalian cells. A mutant designated as apg1 (autophagy) defective in accumulation of autophagic bodies in the vacuoles was isolated by selection using a light microscope from a mutagenized proteinase-deficient strain. In the apg1 strain, which has [...]

Authors: Sullivan M, Katon W, Russo J, Dobie R, Sakai C PMID: 8215728 Abstract Objective: To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus. Design: A 12-week, double-blind, randomized controlled trial. Setting: A university otolaryngology clinic. Patients: Ninety-two subjects with severe [...]

Auhtors: Takeshige K, Baba M, Tsuboi S, Noda T, Ohsumi Y PMID: 1400575 PMCID: PMC2289660 DOI: 10.1083/jcb.119.2.301 Abstract For determination of the physiological role and mechanism of vacuolar proteolysis in the yeast Saccharomyces cerevisiae, mutant cells lacking proteinase A, B, and carboxypeptidase Y were transferred from a nutrient medium to a synthetic medium devoid of [...]

To assess the effect of ivermectin on immune function (antibody production), male CD-1 mice were inoculated with an antigen the day after SC administration of ivermectin (0.2 mg/kg of body weight or 20 mg/kg). Responses were evaluated 5 days after inoculation of the antigen. Antibody production against sheep RBC, a T lymphocyte-, macrophage-dependent response, was enhanced by ivermectin treatment (P = 0.00049). In contrast, antibody production against dinitrophenyl-Ficoll, a T lymphocyte-independent, macrophage-dependent response, was not altered by ivermectin treatment. Results indicate that the immunostimulatory properties of ivermectin are associated with altered function of T lymphocytes, in particular, T-helper lymphocytes. The immunomodulating effects of ivermectin may provide an alternative approach for treatment of disease problems involving immunosuppression.

Authors: Blackshear JL, Orlandi C, Hollenberg NK PMID: 1708058 DOI: 10.1097/00005344-199101000-00010 Abstract Serotonin (5HT) has been implicated in the pathogenesis of several arterial disorders. Experimental intrarenal infusion of 5HT has produced initial decreases, and later sustained increases in total renal blood flow in the dog, and flow limiting renal artery spasm in other species. We [...]

Authors: Ader AW, Paul TL, Reinhardt W, Safran M, Pino S, McArthur W et al. PMID: 3350910 DOI: 10.1210/jcem-66-3-632 Abstract A prospective study was conducted to investigate the effect of long term therapy with two iodine-containing mouth rinses on thyroid function. Two groups of subjects were treated daily for 6 months with either a 5% [...]

Auhtors: Israel BA, Schaeffer WI. PMID: 3654482 DOI: 10.1007/BF02621071 Abstract Using both normal and transformed rat liver epithelial cells to prepare cytoplasmic hybrids (cybrids) we have found evidence to support the theory that the cytoplasm from a normal cell can suppress tumorigenicity. A unique aspect of this study is that all of the cells utilized, [...]

Auhtors: Keys A, Mienotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R, Keys MH PMID: 3776973 DOI: 10.1093/oxfordjournals.aje.a114480 Abstract In 15 cohorts of the Seven Countries Study, comprising 11,579 men aged 40-59 years and "healthy" at entry, 2,288 died in 15 years. Death rates differed among cohorts. Differences in mean age, blood pressure, serum [...]

Authors: Dawson C, Christensen CW, Rickaby DA, Linehan JH, Johnston MR PMID: 2409068 DOI: 10.1152/jappl.1985.58.6.1761 Abstract We examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of [3H]serotonin and the extravascular volume accessible to [14C]antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin [...]