Authors: Ci X, Li H, Yu Q, Zhang X, Yu L, Chen N et al. PMID: 19453757 DOI: 10.1111/j.1472-8206.2009.00684.x Abstract Lipopolysaccharide (LPS) can induce mouse macrophages to produce a number of cytokines and other inflammatory mediators. Immunopharmacological studies can provide new information on the immunomodulatory activities of some drugs, including their effect on cytokine productions. [...]

Authors:Reichling J, Schnitzler P, Suschke U, Saller R. PMID:19420953 DOI: 10.1159/000207196 Abstract The abundant use of anti-infective agents resulted in the emergence of drug-resistant bacteria, fungi, and viruses. To overcome the increasing resistance of pathogenic microbes, a variety of medicinal plants have been screened worldwide for their antimicrobial properties. The aim is to find new, [...]

Auhtors: Bonorden MJ, Rogozina OP, Kluczny CM, Grossmann ME, Grambsch PL, Grande JP, Perkins S PMID: 19235043 DOI: 10.1080/01635580802419798 Abstract Prostate cancer is the most frequently diagnosed cancer in men. Whereas chronic calorie restriction (CCR) delays prostate tumorigenesis in some rodent models, the impact of intermittent caloric restriction (ICR) has not been determined. Here, transgenic [...]

Authors: Hosseinzadeh A, Kamrava SK, Moore BC, Reiter RJ, Ghaznavi HK PMID: 30892162 DOI: 10.2174/1389450120666190319162147 Abstract Tinnitus is a hearing disorder characterized by the perception of sound without external acoustic stimuli, which is caused by damage to the auditory system in response to excessive levels of noise, ototoxic agents and aging. Neural plasticity, oxidative/nitrosative stress [...]

Auhtors: Mathupala SP, Ko YH, Pedersen PL PMID: 19101634 PMCID: PMC2714668 DOI: 10.1016/j.semcancer.2008.11.006 Abstract The most common metabolic hallmark of malignant tumors, i.e., the "Warburg effect" is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen. The pivotal player in this frequent cancer phenotype is mitochondrial-bound [...]

Auhtors: Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, et al. Abstract Pirh2 (p53-induced RING-H2 domain protein; also known as Rchy1) is an E3 ubiquitin ligase involved in a negative-feedback loop with p53. Using NMR spectroscopy, we show that Pirh2 is a unique cysteine-rich protein comprising three modular domains. The protein [...]

Auhtors: Kilkkinen A, Rissanen H, Klaukka T, Pukkala E, Heliövaara M, Huovinen P, et al. PMID: 18704945 DOI: 10.1002/ijc.23622 Abstract Antibiotic use has been hypothesized to be associated with the risk of cancer but the evidence is sparse and inconsistent. The aim of the present study was to determine whether antibiotic use predicts the development [...]

Authors: Zhang X, Song Y, Ci X, An N, Ju Y PMID: 19109745 DOI: 10.1007/s00011-008-8007-8 Abstract Objective and design: To investigate whether ivermectin, a semi-synthetic derivative of a family of macrocyclic lactones could inhibit lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro. Materials and methods: C57BL/6 mice were administered ivermectin (or saline) orally and challenged [...]

Authors: Hamad I, Hunter AC, Szebeni J, Moghimi SM PMID: 18849076 DOI: 10.1016/j.molimm.2008.08.276 Abstract Poly(ethylene glycol) (PEG) is receiving increasing attention as an intravenous therapeutic agent per se in a variety of experimental therapeutics and veterinary settings, such as spinal cord injury and traumatic axonal brain injury. PEG is often perceived to be immunologically safe, [...]

Auhtors: Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN PMID: 18703489 PMCID: PMC2582368 DOI: 10.1194/jlr.M800319-JLR200 Abstract Otto Warburg first proposed that cancer originated from irreversible injury to mitochondrial respiration, but the structural basis for this injury has remained elusive. Cardiolipin (CL) is a complex phospholipid found almost exclusively in the inner mitochondrial membrane [...]