Auhtors: Kvaavik E, Batty GD, Ursin G, Huxley R, Gale CR PMID: 20421558 DOI: 10.1001/archinternmed.2010.76 Abstract Background: Physical activity, diet, smoking, and alcohol consumption have been shown to be related to mortality. We examined prospectively the individual and combined influence of these risk factors on total and cause-specific mortality. Methods: The prospective cohort study included [...]

Auhtors: Nimptsch K, Rohrmann S, Kaaks R, Linseisen J PMID: 20335553 DOI: 10.3945/ajcn.2009.28691 Abstract Background: Anticarcinogenic activities of vitamin K have been observed in animal and cell studies. Objective: On the basis of the growth inhibitory effects of vitamin K as observed in a variety of cancer cell lines, we hypothesized that dietary intake of [...]

Auhtors: Schmid K, Kuwert T, Drexler H PMID: 20386676 PMCID: PMC2853156 DOI: 10.3238/arztebl.2010.0181 Abstract Background: Occupational medicine has long recognized radon to be a cause of lung cancer, especially among miners working under ground. Until recently, however, little scientific evidence was available about the risk to the general population caused by indoor radon. Methods: The [...]

Authors: Harasstaini OA, Moin S, Tham CL, Liew CY, Ismail N, Israf DA PMID: 20221843 DOI: 10.1007/s00011-010-0182-8 Abstract Objectives: We evaluated several flavonoid combinations for synergy in the inhibition of proinflammatory mediator synthesis in the RAW 264.7 cellular model of inflammation. Methods: The inhibitory effect of chrysin, kaempferol, morin, silibinin, quercetin, diosmin and hesperidin upon [...]

Authors: Ng WK, Rosenblatt Y, Brock GB, O'Gorman DB, Gan BS PMID: 21358864 PMCID: PMC2851459 Abstract The treatment of digital ischemia remains difficult. Sildenafil (Viagra, Pfizer UK), a selective phosphodiesterase inhibitor, increases blood flow and is currently marketed for the treatment of erectile dysfunction. A case of a 57-year-old man with progressive episodic ischemia and [...]

Auhtors: Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C PMID: 20053782 PMCID: PMC3041017 DOI: 10.1158/1535-7163.MCT-09-0771 Abstract Notch signaling plays a crucial role in the development of colon cancer; targeting the Notch pathway may sensitize colon cancers to various adjuvant agents. The focus of our current study is to identify natural compounds that target [...]

Abstract Endothelial barrier dysfunction contributes to morbidity in sepsis. We tested the hypothesis that raising the intracellular ascorbate concentration protects the endothelial barrier from septic insult by inhibiting protein phosphatase type 2A.

Authors: Chowanadisiai W, Bauerly KA, Tchaparian E, Wong A, Rucker RB PMID: 19861415 PMCID: PMC2804159 DOI: 10.1074/jbc.M109.030130 Abstract Bioactive compounds reported to stimulate mitochondrial biogenesis are linked to many health benefits such increased longevity, improved energy utilization, and protection from reactive oxygen species. Previously studies have shown that mice and rats fed diets lacking in [...]

Auhtors: Pan PY, Ma G, Weber KJ, Ozao-Choy J, Wang G, Yin B, et al. PMID: 19996287 PMCID: PMC2805053 DOI: 10.1158/0008-5472.CAN-09-1882 Abstract Immune tolerance to tumors is often associated with accumulation of myeloid-derived suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In tumor-bearing mice, MDSCs can themselves facilitate the generation [...]

Authors: MacDonald K, McDonald TM PMID: 20047458 DOI: 10.3109/10673220903523615 Abstract Oxytocin is a neuropeptide involved in a wide variety of social behaviors in diverse species. Recent research on its effects in humans has generated an arresting picture of its role in the dynamic function of the social brain. This review presents a broad overview of [...]