Abstract To gain insight into the commercial changes occurring in the oncology industry, Campbell Alliance initiated the Oncology National Commercial (ONC) study where 75 key industry experts, physicians, payers, and opinion leaders were surveyed. The study revealed an alarming pattern that told us that the oncology space is transforming in such a way that never-before-seen [...]

Authors: Allen J, Bradley RD PMID: 21875351 PMCID: PMC3162377 DOI: 10.1089/acm.2010.0716 Abstract Background: The tripeptide glutathione (GSH) is the most abundant free radical scavenger synthesized endogenously in humans. Increasing mechanistic, clinical, and epidemiological evidence demonstrates that GSH status is significant in acute and chronic diseases. Despite ease of delivery, little controlled clinical research data exist [...]

Auhtors: Seyfried TN, Kiebish MA, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P PMID: 20804725 DOI: 10.1016/j.bbabio.2010.08.009 Abstract Malignant brain tumors are a significant health problem in children and adults. Conventional therapeutic approaches have been largely unsuccessful in providing long-term management. As primarily a metabolic disease, malignant brain cancer can be managed through changes in [...]

Authors: Bismuth-Evenzal Y, Gonopolsky Y, gurwitz D, Iancu I, Weizman A PMID: 21893349 DOI: 10.1016/j.jad.2011.08.013 Abstract Background: Chronic treatment with selective serotonin reuptake inhibitors (SSRIs) reduces the risk and severity of cardiovascular diseases. SSRIs block the serotonin transporter, thereby inhibiting serotonin (5-HT) uptake into presynaptic neurons as well as into platelets [...]

Auhtors: Little JP, Gillen JB, Percival ME, Safdar A, Tarnopolsky MA, Punthakee Z, et al. PMID: 21868679 DOI: 10.1152/japplphysiol.00921.2011 Abstract Low-volume high-intensity interval training (HIT) is emerging as a time-efficient exercise strategy for improving health and fitness. This form of exercise has not been tested in type 2 diabetes and thus we examined the effects [...]

The aim of the present study is to summarize existing literature on vitamin D levels in adults in different continents and different countries worldwide. The best determinant of vitamin D status is the serum concentration of 25-hydroxyvitamin D (25(OH)D).

Auhtors: Singh BN, Shankar S, Srivastava RK PMID: 21827739 PMCID: PMC4082721 DOI: 10.1016/j.bcp.2011.07.093 Abstract An expanding body of preclinical evidence suggests EGCG, the major catechin found in green tea (Camellia sinensis), has the potential to impact a variety of human diseases. Apparently, EGCG functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but [...]

Auhtors: Chen X, Lu W, Zheng W, Gu K, Matthews CE, Chen Z, et al. PMID: 21795422 PMCID: PMC3169008 DOI: 10.1158/1940-6207.CAPR-10-0355 Abstract It has been suggested that exercise following breast cancer diagnosis is inversely associated with mortality. However, controversy exists regarding the causality of such associations. We evaluated associations of exercise after breast cancer diagnosis [...]

Authors: Clarke JD, Hsu A, Riedl K, Bella D, Stevens JF, Ho E PMID: 21816223 PMCID: PMC3183106 DOI: 10.1016/j.phrs.2011.07.005 Abstract Broccoli consumption may reduce the risk of various cancers and many broccoli supplements are now available. The bioavailability and excretion of the mercapturic acid pathway metabolites isothiocyanates after human consumption of broccoli supplements has not [...]

Auhtors: Baldwin C, Spiro A, McGough C, Norman AR, Gillbanks A, Thomas K, et al. PMID: 21733143 DOI: 10.1111/j.1365-277X.2011.01189.x Abstract Background: Weight loss in patients with cancer is common and associated with a poorer survival and quality of life. Benefits from nutritional interventions are unclear. The present study assessed the effect of dietary advice and/or [...]