Auhtors: Meynet O, Ricci JE PMID: 24916302 DOI: 10.1016/j.molmed.2014.05.001 Abstract Caloric restriction (CR) is currently the most robust environmental intervention known to increase healthy life and prolong lifespan in several models, from yeast to mice. Although the protective effect of CR on the incidence of cancer is well established, its impact on tumor cell responses [...]

Authors: Hine C, Mitchell JR PMID: 24905161 PMCID: PMC4278638 DOI: 10.1016/j.stem.2014.05.016 Abstract Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic [...]

Authors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal [...]

Auhtors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS. PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction [...]

Authors: Valentova K, Vrba J, Bancirova M, Ulrichova J. PMID: 24680690 DOI: 10.1016/j.fct.2014.03.018 Abstract The flavonoid isoquercitrin (quercetin-3-O-β-d-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and "enzymatically modified (α-glucosylated) isoquercitrin" (EMIQ). Pure isoquercitrin can now [...]

Authors: Mooventhan A, Nivethitha L PMID: 24926444 PMCID: PMC4049052 DOI: 10.4103/1947-2714.132935 Abstract The use of water for various treatments (hydrotherapy) is probably as old as mankind. Hydrotherapy is one of the basic methods of treatment widely used in the system of natural medicine, which is also called as water therapy, aquatic therapy, pool therapy, and [...]

Auhtors: Teicholz N Abstract In The Big Fat Surprise, investigative journalist Nina Teicholz reveals the unthinkable: that everything we thought we knew about dietary fat is wrong. She documents how the low-fat nutrition advice of the past 60 years has amounted to a vast uncontrolled experiment on the entire population, with disastrous consequences for our [...]

Auhtors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC, Fuchs CS PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]

Authors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC et al. PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]

Auhtors: Anglemyer A, Horvath HT, Bero L PMID: 24782322 PMCID: PMC8191367 DOI: 10.1002/14651858.MR000034.pub2 Abstract Background: Researchers and organizations often use evidence from randomized controlled trials (RCTs) to determine the efficacy of a treatment or intervention under ideal conditions. Studies of observational designs are often used to measure the effectiveness of an intervention in 'real world' [...]