Authors: Dhooria S, Chaudhary S, Sehgal IS, Agarwal R, Arora S PMID: 34887325 PMCID: PMC8850687 DOI: 10.1183/13993003.02930-2021 Abstract High-dose prednisolone may not be superior to a low-dose 6-week regimen in improving clinical, physiological and radiological outcomes, or health-related quality of life, in patients with symptomatic post-COVID-19 diffuse parenchymal lung abnormalities. Keywords: prednisolone, Long COVID, COVID-19 [...]

Authors: Hazan S, Dave S, Gunaratne AW, Dolai S, Clancy RL, McCullough PA et al. PMID: 35135310 PMCID: PMC8826831 DOI: 10.2217/fmb-2022-0014 Abstract Aims: Ivermectin is a safe, inexpensive and effective early COVID-19 treatment validated in 20+ random, controlled trials. Having developed combination therapies for Helicobacter pylori, the authors present a highly effective COVID-19 therapeutic [...]

Authors:Dror AA, Morozov N, Daoud A, Namir Y, Yakir O. PMID: PMC8812897 DOI: 10.1371/journal.pone.0263069 AbstractObjective: Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists [...]

Authors: Cereda G, Ciappolino V, Boscutti A, Cantu F, Enrico P, Oldani L PMID: 34634109 PMCID: PMC8524565 DOI: 10.1093/advances/nmab110 Abstract The outbreak of the pandemic associated with Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) led researchers to find new potential treatments, including nonpharmacological molecules such as zinc (Zn2+). Specifically, the use of Zn2+ as a [...]

Authors: Patterson B, Yogendra R, Guevara-Coto J, Osgood E, Bream J, Parikh P DOI:10.21203/rs.3.rs-1344323/v1 Abstract Post-acute sequelae of COVID (PASC), or long COVID, is a multisystem complication of SARS-CoV-2 infection that continues to debilitate millions worldwide thus highlighting the public health importance of identifying effective therapeutics to alleviate this illness. The [...]

Authors: Jeffreys L, Pennington SH, Duggan J, Breen A, Jinks J PMID: 35093538 PMCID: PMC8801767 DOI: 10.1016/j.ijantimicag.2022.106542 Abstract A key element for the prevention and management of coronavirus disease 2019 is the development of effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have the potential to achieve greater efficacy, to increase the [...]

Auhtors: Vasim I, Majeed CN, DeBoer MD PMID: 35276989 PMCID: PMC8839325 DOI: 10.3390/nu14030631 Abstract Given the ongoing strain that the obesity epidemic has placed on public health outcomes, new and effective approaches to weight control are needed. One approach to improving weight and metabolic outcomes is intermittent fasting, which consists of multiple different timing schedules [...]

Auhtors: Kolawole OR, Kashfi K PMID: 35163356 PMCID: PMC8836048 DOI: 10.3390/ijms23031432 Abstract Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is self-limiting, which returns the body to a state of homeostasis. However, unresolved, uncontrolled, or chronic inflammation may lead to various maladies, including cancer. Important evidence that links inflammation and cancer [...]

Authors: Willett BJ, Grove J, MacLean OA, Willkie C, Logan N doi: https://doi.org/10.1101/2022.01.03.21268111 Abstract Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron, the fifth VOC to be described, harbours 30 amino [...]

Auhtors: Pliss A, Kuzmin AN, Prasad PN, Mahajan SD PMID: 35049274 PMCID: PMC8790819 DOI: 10.1021/acschemneuro.1c00675 Abstract The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is increasingly attributed to mitochondrial dysfunction of brain microglia cells. However, the changes in biochemical content of mitochondria that drive the progression [...]