Authors: Santamarina MG, Beddings I, Martinez Lomakin F, Boisier Riscal D PMID: 34980198 PMCID: PMC8721481 DOI: 10.1186/s13054-021-03885-y Abstract Background: SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation-perfusion mismatch that can be characterized using subtraction computed tomography angiography (sCTA). This study aims to evaluate [...]

Authors: Mario L, Roberto M, Marta L, Teresa CM, Laura M PMID: 32939238 PMCID: PMC7478270 doi: 10.4103/ijpvm.IJPVM_258_20 Abstract Backgound: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible [...]

Authors: Kniotek M, Boguska A PMID: 28316997 PMCID: PMC5337856 DOI: 10.1155/2017/4541958 Abstract Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5. cGMP is a secondary messenger activating protein kinases and a common [...]

Auhtors: Mei XL, Yang Y, Zhang YJ, Li Y, Zhao JM, Qiu JG, et al. PMID: 26807313 PMCID: PMC4697679 Abstract Colorectal cancer is the third most common human cancer with frequent overexpression of the cGMP-specific phosphodiesterase 5 (PDE5). In the present study, we investigated that the anticancer effect of sildenafil on human colorectal cancer in [...]