Authors: Caplan M, Goutay J, Bignon A, Jaillette E, Favory R PMID: 33093279 DOI: 10.1097/CCM.0000000000004711 Abstract Objectives: Treating acute respiratory failure in patients with coronavirus disease 2019 is challenging due to the lack of knowledge of the underlying pathophysiology. Hypoxemia may be explained in part by the loss of hypoxic pulmonary vasoconstriction. The present study [...]

Authors: Raman B, Cassar MP, Tunnicliffe EM, Filippini N, Griffanti L, Okell T et al. PMID: 33490928 PMCID: PMC7808914 DOI: 10.1016/j.eclinm.2020.100683 Abstract Background: The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood. Methods: Fifty-eight COVID-19 patients post-hospital discharge [...]

Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.

Martin D. Hellwig a, Anabela Maia b https://doi.org/10.1016/j.ijantimicag.2020.106248 Abstract As COVID-19 (coronavirus disease 2019) continues to rapidly spread throughout the world, the incidence varies greatly among different countries. These differences raise the question whether nations with a lower incidence share any medical commonalities that could be used not only to explain that lower incidence [...]

The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death.

Continued uncontrolled transmission of the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in many parts of the world is creating the conditions for significant virus evolution. Here, we describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y) that may have functional significance. This lineage emerged in South Africa after the first epidemic wave in a severely affected metropolitan area, Nelson Mandela Bay, located on the coast of the Eastern Cape Province. This lineage spread rapidly, becoming within weeks the dominant lineage in the Eastern Cape and Western Cape Provinces. Whilst the full significance of the mutations is yet to be determined, the genomic data, showing the rapid displacement of other lineages, suggest that this lineage may be associated with increased transmissibility.

Authors: Fatima S, Zaidi SS, Alsharidah AS, Alijaser FS, Banu N PMID: 33344529 PMCID: PMC7744567 DOI: 10.3389/fvets.2020.585789 Abstract SARS-CoV-2, an epidemic, causes severe stress in both human and animals and may induce oxidative stress (OS) and increases susceptibility to infection. Domestic animals are found infected by their COVID-2 suffering owners. Chronic immobilization stress (CIS), a [...]

Authors: Peralta EG, Fimia-Duarte R, Cardenas JW, Dominguez DV, Segura RB Abstract Covid-19 is one of the viral infections that have always accompanied us. In some years harmless, but from time to time with a higher risk potential. What is particularly unsettling for us is that transmission often occurs from a [...]

Authors: Wood E, Hall KH, Tate W PMID: 33251031 PMCID: PMC7680046 DOI: 10.1016/j.cdtm.2020.11.002 Abstract A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, [...]

Authors: Clausen TM, Sandoval DR, Spliid CB, PiHl J, Painter CD, Thacker BE et al. PMID: 32970989 PMCID: PMC7489987 DOI: 10.1016/j.cell.2020.09.033 Abstract We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding [...]