Auhtors: Hwang CY, Choe W, Yoon KS, Ha J, Kim SS, Yeo EJ, Kang I PMID: 36432618 PMCID: PMC9694619 DOI: 10.3390/nu14224932 Abstract The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic ketogenesis are catabolized to acetyl-CoA through ketolysis in extrahepatic tissues, followed by [...]

Auhtors: Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, et al. PMID: 29657030 PMCID: PMC5932217 DOI: 10.1016/j.cmet.2018.03.002 Abstract Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated [...]

Auhtors: Oizel K, Chauvin C, Oliver L, Gratas C, Geraldo F, Jarry U, et al. PMID: 28720668 DOI: 10.1158/1078-0432.CCR-16-3102 Abstract Purpose: Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism is a new attractive therapeutic target in cancer; [...]

Auhtors: Puchalska P, Crawford PA PMID: 28178565 PMCID: PMC5313038 DOI: 10.1016/j.cmet.2016.12.022 Abstract Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states and protect from inflammation and injury in multiple organ systems. Traditionally [...]

Auhtors: Seyfried TN Abstract The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was [...]

Auhtors: Ramanathan A, Wang C, Schreiber SL PMID: 15840712 PMCID: PMC1087961 DOI: 10.1073/pnas.0502267102 Abstract Weinberg and coworkers have used serial transduction of a human, primary fibroblast cell line with the catalytic domain of human telomerase, large T antigen, small T antigen, and an oncogenic allele of H-ras to study stages leading toward a fully transformed [...]

Auhtors: Warburg O, Wind F, Negelein E PMID: 19872213 PMCID: PMC2140820 DOI: 10.1085/jgp.8.6.519 Abstract In this contribution we discuss the question of whether tumor cells in living animals can be killed off through lack of energy, and the related question of how the tumors are supplied with oxygen and glucose in the body. We assume [...]