Auhtors: Warburg O, Wind F, Negelein E
PMID: 19872213 PMCID: PMC2140820 DOI: 10.1085/jgp.8.6.519
Abstract
In this contribution we discuss the question of whether tumor cells in living animals can be killed off through lack of energy, and the related question of how the tumors are supplied with oxygen and glucose in the body. We assume it is understood that tumor cells obtain the energy required for their existence in two ways: by respiration and by fermentation. In respiration they burn organic materials to carbon dioxide and water; in fermentation they split glucose to lactic acid. All tumors so far tested behave fundamentally alike. There is no essential difference between the cancer cells of transplanted rat tumors and spontaneous tumors, sarcoma and carcinoma cells, and the tar carcinoma, and Rous sarcoma produced by filtrate.
Keywords: tumors, metabolism
