Auhtors: Gyori D, Lim EL, Grant FM, Spensberger D, Roychoudhuri R, Shuttleworth SJ, et al. PMID: 29875321 PMCID: PMC6124419 DOI: 10.1172/jci.insight.120631 Abstract Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by limiting antitumor immunity. Here we [...]

Auhtors: Yuan X, Zhang J, Li D, Mao Y, Mo F, Du W, Ma X PMID: 28698008 DOI: 10.1016/j.ygyno.2017.07.007 Abstract Objective: The role of tumor-associated macrophages (TAMs) in tumor microenvironment remains controversial due to the two different polarized subsets of TAMs. Here, we performed a meta-analysis to evaluate the correlation between subpopulations of TAMs and [...]

Auhtors: Zhao X, Qu J, Sun Y, Wang J, Liu x, Wang F, et al. PMID: 28427165 PMCID: PMC5444766 DOI: 10.18632/oncotarget.15736 Abstract Purpose: Tumor associated macrophages (TAMs) are important prognostic factors and have been proved to be associated with the invasion and migration of various cancer. However, the relationship between TAMs and breast cancer outcomes [...]

Auhtors: Ruffell B, Coussens LM. PMID: 25858805 PMCID: PMC4400235 DOI: 10.1016/j.ccell.2015.02.015 Abstract How neoplastic cells respond to therapy is not solely dependent on the complexity of the genomic aberrations they harbor but is also regulated by numerous dynamic properties of the tumor microenvironment. Identifying and targeting critical pathways that improve therapeutic efficacy by bolstering anti-tumor [...]

Auhtors: Beury DW, Parker KH, Nyandjo M, Sinha P, Carter KA, Ostrand-Rosenberg S PMID: 25170116 PMCID: PMC4226789 DOI: 10.1189/jlb.3A0414-210R Abstract MDSC and macrophages are present in most solid tumors and are important drivers of immune suppression and inflammation. It is established that cross-talk between MDSC and macrophages impacts anti-tumor immunity; however, interactions between tumor cells [...]

Auhtors: Komohara Y, Jinushi M, Takeya M PMID: 24168081 PMCID: PMC4317877 DOI: 10.1111/cas.12314 Abstract The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known. With the recent introduction of the novel concept of macrophage differentiation into a classically activated phenotype (M1) and an alternatively activated phenotype (M2), [...]

Auhtors: Chen Q, Zhang XH, Massagu J PMID: 22014578 PMCID: PMC3293160 DOI: 10.1016/j.ccr.2011.08.025 Abstract Aberrant expression of vascular cell adhesion molecule-1 (VCAM-1) in breast cancer cells is associated with lung relapse, but the role of VCAM-1 as a mediator of metastasis has remained unknown. We report that VCAM-1 provides a survival advantage to breast cancer [...]

Auhtors: Murray PJ, Wynn TA PMID: 21997792 PMCID: PMC3422549 DOI: 10.1038/nri3073 Abstract Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local [...]