Auhtors: Li X, Liu R, Su X, Pan Y, Han X, Shao C, Shi Y PMID: 31805946 PMCID: PMC6894344 DOI: 10.1186/s12943-019-1102-3 Abstract Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients [...]

Auhtors: Wu T, Wu X, Wang HY, Chen L PMID: 30999966 PMCID: PMC6471962 DOI: 10.1186/s40880-019-0365-9 Abstract Tumor immune microenvironment is closely related to tumor initiation, prognosis, and response to immunotherapy. The immune landscapes, number of infiltrating immune cells, and the localization of lymphocytes in the tumor vary in across different types of tumors. The immune [...]

Auhtors: Gyori D, Lim EL, Grant FM, Spensberger D, Roychoudhuri R, Shuttleworth SJ, et al. PMID: 29875321 PMCID: PMC6124419 DOI: 10.1172/jci.insight.120631 Abstract Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by limiting antitumor immunity. Here we [...]

Auhtors: Becht E, Giraldo NA, Dieu-Nosjean MC, Sautès-Fridman C, Fridman WH PMID: 26708937 DOI: 10.1016/j.coi.2015.11.009 Abstract The immune contexture that characterizes the density, the location, the organization and the functional orientation of tumor-infiltrating immune cells in cancers has a clinical impact on patient's outcome. It is, in great part, shaped by the malignant cells, as [...]

Auhtors: Giraldo NA, Becht E, Remark R, Damotte D, Sautès-Fridman C, Fridman WH PMID: 24487185 DOI: 10.1016/j.coi.2014.01.001 Abstract A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates [...]