Authors: Spagnolo P, Balestro E, Aliberti S, Cocconcelli E, Biondini D, Casa GD PMID: 32422177 PMCID: PMC7228737 DOI: 10.1016/S2213-2600(20)30222-8 Abstract As of May 6, 2020, nearly 3·7 million people have been infected and around 260 000 people have died from coronavirus disease 2019 (COVID-19) worldwide.1 Almost all COVID-19-related serious consequences feature pneumonia.2 In the first large [...]

Authors: Chiumello D, Cressoni M, Gattinoni L PMID: 32228035 PMCID: PMC7233352 DOI: 10.1164/rccm.202003-0817LE Abstract In northern Italy, an overwhelming number of patients with coronavirus disease (COVID-19) pneumonia and acute respiratory failure have been admitted to our ICUs. Attention is primarily focused on increasing the number of beds, ventilators, and intensivists brought to bear on the [...]

Authors: Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S PMID: 32416070 PMCID: PMC7227586 DOI: 10.1016/j.cell.2020.04.026 Abstract Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an [...]

The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of thousands of individuals worldwide. This highly infectious condition continues to ravage the world population and has yet to reach it peak infective rate in some countries.

Authors: Chroboczek T, Lacoste M, Wackenheim C, Challan-Belval T, Amar B, Boisson T doi: https://doi.org/10.1101/2020.05.08.20094755 Abstract Background Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for Coronavirus Disease 2019 (COVID-19), is spreading worldwide, causing significant morbidity and mortality. No specific treatment has yet clearly shown to improve the disease’s evolution. Validated therapeutic [...]

Authors: Kurcicka L, Lauer SA, Laeyendecker O, Boon D, Lessler J PMID: 32422057 PMCID: PMC7240870 DOI: 10.7326/M20-1495 Abstract Background: Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse transcriptase polymerase chain reaction (RT-PCR) are being used to rule out infection among high-risk persons, such as exposed inpatients and health care workers. It [...]

Authors: Wahedi HM, Ahmad S, Abbasi SW PMID: 32345140 DOI: 10.1080/07391102.2020.1762743 Abstract The pandemic coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a great threat to public health. Currently, no potent medicine is available to treat COVID-19. Quest for new drugs especially from natural plant sources is an area of [...]

Authors: Banerjee A, Pasea L, Harris S, Gonzalez-Izquierdo A PMID: 32405103 PMCID: PMC7217641 DOI: 10.1016/S0140-6736(20)30854-0 Abstract Background: The medical, societal, and economic impact of the coronavirus disease 2019 (COVID-19) pandemic has unknown effects on overall population mortality. Previous models of population mortality are based on death over days among infected people, nearly all of whom [...]

Authors: Wang J, Najizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA PMID: 32267998 PMCID: PMC7262152 DOI: 10.1111/jth.14828 Abstract A prothrombotic coagulopathy is commonly found in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS). A unique feature of COVID-19 respiratory failure is a relatively preserved lung compliance and high Alveolar-arterial oxygen gradient, [...]

The pathogenesis of a COVID-19 respiratory infection, in a major way, is related to what is referred to as the cytokine storm [cytokine storm syndrome (CSS, hypercytokinemia, etc.], i.e., it is a hyper-inflammatory response.