Authors: Liu J, Zheng X, Huang Y, Shan H, Huang J PMID: 32479759 PMCID: PMC7256545 DOI: 10.1016/j.jaci.2020.05.021 Abstract As of April 4, 2020, a total of 1,051,635 coronavirus disease 2019 (COVID-19) cases had been reported worldwide, among which 56,985 deaths occurred (5.42%).1 However, to date, no vaccine and no specific antiviral medicine are available to [...]

Authors: Unal G, Turan B, Balcioglu YH PMID: 32498007 PMCID: PMC7255327 DOI: 10.1016/j.mehy.2020.109891 Abstract Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) which leads to COVID-19, was first seen in Wuhan province of China in December 2019 and spread globally in a short time. COVID-19 was announced as a pandemic by WHO on March 11th, 2020 and approximately [...]

Authors: Xu Q, Wang T, Quin X, Zha L PMID: 32448330 PMCID: PMC7246000 DOI: 10.1186/s13054-020-02991-7 Abstract Coronavirus disease 2019 (COVID-19) has rapidly spread around the world in the past 3 months and has now become a global public health crisis. The mortality of COVID-19 in some European cities exceeds 11%, and the fatality rate is [...]

Authors: Tripathy S, Dassarma B, Roy S, Chabalala H, Matsabisa MG PMID: 32450198 PMCID: PMC7243790 DOI: 10.1016/j.ijantimicag.2020.106028 Abstract Chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have long been used worldwide as frontline drugs for the treatment and prophylaxis of human malaria. Since the first reported cases in Wuhan, China, in late December 2019, humans have [...]

Authors: Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R et al. PMID: 33795830 PMCID: PMC8015313 DOI: 10.1038/s41379-021-00793-y Abstract BACKGROUND Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe, disproportionately affecting New York City. A comprehensive, integrative autopsy series that [...]

Authors: Freedberg DE, Conigliaro J, Sobieszczyk ME, Markowitz DD PMID: 32446698 PMCID: PMC7242191 doi: 10.1053/j.gastro.2020.05.053 Abstract Coronavirus Disease 2019 (COVID-19) caused 2 million cases and more than 150,000 deaths worldwide as of mid-April 2020.1 Clinical trials are under way to assess the efficacy of a variety of antiviral drugs; however, many of these drugs have [...]

Authors: Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T PMID: 32437596 PMCID: PMC7412750 DOI: 10.1056/NEJMoa2015432 Abstract Background: Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated [...]

Authors: Teuwen LA, Geldhof V, Pasut A, Carmeliet P PMID: 32439870 PMCID: PMC7240244 DOI: 10.1038/s41577-020-0343-0 Abstract On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endothelial cells, viral infection [...]

Authors: De Maio A, Hightower LE PMID: 32424591 PMCID: PMC7232923 DOI: 10.1007/s12192-020-01121-0 Abstract The current coronavirus disease 2019 (COVID-19) pandemic has become an unprecedented challenge for the healthcare system worldwide, with an overwhelming number of patients requiring clinical attention and an unacceptably high mortality rate within critical care facilities. COVID-19 is caused by a novel [...]

Authors: George PM, Wells AU, Jenkins RG PMID: 32422178 PMCID: PMC7228727 DOI: 10.1016/S2213-2600(20)30225-3 Abstract In December, 2019, reports emerged from Wuhan, China, of a severe acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the end of April, 2020, over 3 million people had been confirmed infected, with over 1 million [...]