Authors: Buijsers B, Yanginlar C, de Nooijer A, Grondman I, Jonkman I, Rother N PMID: 33123154 PMCID: PMC7573491 DOI: 10.3389/fimmu.2020.575047 Abstract Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation. Low molecular weight [...]

Authors: Tomazini BM, Maia IS, Cavalcanti AB, Berwanger O, Rosa RG, Veiga VC PMID: 32876695 PMCID: PMC7489411 DOI: 10.1001/jama.2020.17021 Abstract Importance: Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these patients. Objective: To determine [...]

Authors: Jonathan A C Sterne, Srinivas Murthy, Janet V Diaz, et al. PMID: 32876694 PMCID: PMC7489434 DOI: 10.1001/jama.2020.17023 Abstract Importance: Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support. Objective: To estimate the [...]

Authors: DiNicolantonio JJ, Barroso-Arranda J, McCarty M PMID: 32895293 PMCID: PMC7476419 DOI: 10.1136/openhrt-2020-001350 Abstract Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including river blindness and lymphatic filariasis. It is also widely [...]

Authors: Schiaffino MT, Di Natale M, Garcia-Martinez E, Navarro J, Munoz-Blanco JL, Demelo-Rodriguez P PMID: 32738141 PMCID: PMC7454719 DOI: 10.1093/infdis/jiaa485 Abstract Background: During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients. Methods: The IF pattern was composed of liver and gastric [...]

Authors: Senniappan K, Jeyabalan S, Rangappa P, Kanchi M PMID: 33437070 PMCID: PMC7791429 DOI: 10.4103/ija.IJA_613_20 Abstract The coronavirus disease 2019 (COVID-19) is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Although 85% of infected patients remain asymptomatic, 5% show severe symptoms such as hypoxaemic respiratory failure and multiple end organ dysfunction (MODS) [...]

Authors: Sethia R, Prasad M, Mahapatra SJ, Nischal N, Soneja M doi: https://doi.org/10.1101/2020.09.28.20203463 Abstract Background Coronavirus Disease 2019 (COVID-19) pandemic continues unabated in many parts of the world. In the absence of any definite antiviral therapy except some benefit of remdesivir, there is an ongoing search for effective therapy. Famotidine has been shown to reduce [...]

Authors: Schurink B, Roos E, Radonic T, Barbe E, Bouman CS DOI:https://doi.org/10.1016/S2666-5247(20)30144-0 Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets multiple organs and causes severe coagulopathy. Histopathological organ changes might not only be attributable to a direct virus-induced effect, but also the immune response. The aims of this study were to assess the [...]

Authors: Zhang Q, Bastard P, Liu Z, Le Pen J, Chen J, Korol C PMID: 32972995 PMCID: PMC7857407 DOI: 10.1126/science.abd4570 Abstract Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function [...]

Authors: Ruiz-Irastorza G, Pijoan JI, Bereciatua E, Dunder S, Dominguez J, Garcia-Escudero P PMID: 32960899 PMCID: PMC7508405 DOI: 10.1371/journal.pone.0239401 Abstract Objective: To analyze the effects of a short course of methyl-prednisolone pulses (MP) during the second week of disease (week-2) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia. Methods: Comparative observational study using data [...]