Authors: Zaid Y, Guessous F, Puhm F, Elhamdani W, Chentoufi L, Morris AC PMID: 33560374 PMCID: PMC7846461 DOI: 10.1182/bloodadvances.2020003513 Abstract In addition to preserving homeostasis and contributing to immunity, platelets may exhibit a dysregulated state, in acute respiratory distress syndrome (ARDS) and potentially exacerbate lung injury.Although thrombocytopenia has been associated with increased mortality in ARDS,and [...]

Authors: Hinduja A, Moutairou A, Calvet JH PMID: 33551341 PMCID: PMC7835104 DOI: 10.1016/j.neucli.2021.01.003 Abstract Dysautonomia has been reported in COVID-19. Sweat function testing has been proposed to assess autonomic neuropathy. Fifty Indian patients consulting for neurological symptoms participated in this observational study. The NHS questionnaire for neurological symptoms was completed and electrochemical skin conductance was [...]

Authors: Pascolini S, Vannini A, Deleonardi G, Ciordinik M, Sensoli A PMID: 32989903 PMCID: PMC7536986 DOI: 10.1111/cts.12908 Abstract Coronavirus disease 2019 (COVID-19) is often associated with interstitial pneumonia. However, there is insufficient knowledge on the presence of autoimmune serological markers in patients with COVID-19. We analyzed the presence and role of autoantibodies in patients with [...]

Authors: Zhang J, Rao X, Li Y, Zhu Y, Liu G, Guo G et al. PMID: 33420963 PMCID: PMC7794643 DOI: 10.1186/s13613-020-00792-3 Abstract Background: Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was effective for severe COVID-19. Methods: [...]

Authors: Huang C, Huang L, Wang Y, Li X, Ren L, Gu X PMID: 33428867 PMCID: PMC7833295 DOI: 10.1016/S0140-6736(20)32656-8 Abstract Background: The long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate [...]

Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.

PMID: 33555768 Abstract This guideline covers identifying, assessing and managing the long-term effects of COVID-19, often described as ‘long COVID’. It makes recommendations about care in all healthcare settings for adults, children and young people who have new or ongoing symptoms 4 weeks or more after the start of acute COVID-19. It also includes [...]

Authors: Salvarani C, Dolci G, Massari M, Merlo DF, Cavuto S PMID: 33080005 PMCID: PMC7577199 DOI: 10.1001/jamainternmed.2020.6615 Abstract Importance: The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies in patients with COVID-19 pneumonia with a good safety profile. Objective: To evaluate the effect of [...]

Authors: Hermine O, Mariette X, Tharaux PL, Resche-Rignon M, Porcher R PMID: 33080017 PMCID: PMC7577198 DOI: 10.1001/jamainternmed.2020.6820 Abstract Importance: Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19). Objective: To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia. Design, setting, and particpants: This [...]

Martin D. Hellwig a, Anabela Maia b https://doi.org/10.1016/j.ijantimicag.2020.106248 Abstract As COVID-19 (coronavirus disease 2019) continues to rapidly spread throughout the world, the incidence varies greatly among different countries. These differences raise the question whether nations with a lower incidence share any medical commonalities that could be used not only to explain that lower incidence [...]