Authors: Simonovich VA, Pratx LD, Scibona P, Beruto MV, Vallone MG DOI: 10.1056/NEJMoa2031304 Abstract BACKGROUND Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available from adequately powered randomized, controlled trials. METHODS We randomly assigned hospitalized adult [...]

Authors: Al Sulaiman K, Al Juhani O, Badreldin HA, Salah KB, Alharbi A, Arabi YM doi: https://doi.org/10.21203/rs.3.rs-227158/v1 Abstract Background: Due to its supposed clinical efficacy, relative safety, and low cost, ascorbic acid represents an appealing option for clinicians to utilize in the context of a global health pandemic of COVID-19 patients. Objectives: The aim of [...]

Authors: Thompson MA, Henderson JP, Shah PK, Rubenstein SM, Joyner MJ, Flora DB. doi: https://doi.org/10.1101/2021.02.05.21250953 Abstract Convalescent plasma may benefit immunocompromised individuals with COVID-19, including those with hematologic malignancy. We evaluated the association of convalescent plasma treatment with 30-day mortality in hospitalized adults with hematologic malignancy and COVID-19 from a multi-institutional cohort. 143 treated patients [...]

Authors: Wang EY, Mao T, Klein J, Dai Y, Huck JD, Jaycox JR PMID: 33330894 PMCID: PMC7743105 DOI: 10.1101/2020.12.10.20247205 Abstract COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune responses1-8. While pathological innate immune activation is well documented in severe disease1, the impact of autoantibodies on [...]

Authors: Cadegiani FA, McCoy J, Wambier CG, Goren A PMID: 33643746 PMCID: PMC7885746 DOI: 10.7759/cureus.13047 Abstract Background and objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and subsequent infectivity are mediated by androgens and the androgen receptors through the regulation of transmembrane protease, serine 2 (TMPRSS2). Androgenetic alopecia (AGA) [...]

Authors: Sweeney TE, Liesenfeld O, Wacker J, He YD, rawling D, Remmel M PMID: 33201004 DOI: 10.1097/CCM.0000000000004786 AbstractObjectives: Complex critical syndromes like sepsis and coronavirus disease 2019 may be composed of underling "endotypes," which may respond differently to treatment. The aim of this study was to test whether a previously defined bacterial sepsis endotypes classifier [...]

Authors: Logue JK, Franko NM, McCulloch DJ, McDonald D PMID: 33606031 PMCID: PMC7896197 DOI: 10.1001/jamanetworkopen.2021.0830 Abstract This cohort study analyzed persistent symptoms among adults with coronavirus disease 2019 up to 9 months after illness onset. Keywords: sequelae, COVID-19, Long COVID Source: https://pubmed.ncbi.nlm.nih.gov/33606031/ Archive: https://archive.is/ceI49

Authors: Patterson G, Isales CM, Fulzele S PMID: 33532123 PMCID: PMC7801272 DOI: 10.14336/AD.2020.0918 Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been spreading around the world at an exponential pace, leading to millions of individuals developing the associated disease called COVID-19. Due to the novel nature and the lack of immunity within humans, [...]

Authors: Saeedi-Boroujeni A, Mahmoudian-Sani MR. PMID: Abstract SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress [...]

Authors: Tardif JC, Bouabdallaoui N, L'Allier PL, Gaudet D, Shah B, Pillinger MH et al. doi: https://doi.org/10.1101/2021.01.26.21250494 Abstract Background Evidence suggests the role of an inflammatory storm in COVID-19 complications. Colchicine is an orally administered, anti-inflammatory medication beneficial in gout, pericarditis and coronary disease. Methods We performed a randomized, double-blind trial [...]