Auhtors: Morgan G, Ward R, Barton M PMID: 15630849 DOI: 10.1016/j.clon.2004.06.007 Abstract Aims: The debate on the funding and availability of cytotoxic drugs raises questions about the contribution of curative or adjuvant cytotoxic chemotherapy to survival in adult cancer patients. Materials and methods: We undertook a literature search for randomised clinical trials reporting a 5-year [...]

Auhtors: Guezva JM, Krajewska M, de Heredia ML, Krajewski S, Santamaria G, Kim H, et al. PMID: 12438266 Abstract Mitochondrial H+-ATP synthase is required for cellular energy provision and for efficient execution of apoptosis. Almost one century ago, Otto Warburg proposed the hypothesis that mitochondrial function might be impaired in cancer cells. However, his hypothesis [...]

Auhtors: Delsite R, Kachhap S, Anbazhagan R, Gabrielson E, Singh KK PMID: 12495447 PMCID: PMC149409 DOI: 10.1186/1476-4598-1-6 Abstract Background: The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitochondria, mitochondrial DNA (mtDNA) encodes 13 [...]

Auhtors: John AP PMID: 11601863 DOI: 10.1054/mehy.2001.1335 Abstract It has been known for decades that cancer cells produce excessive amounts of lactic acid. The fact that most cancers have poor vascular systems has led cancer scientists to assume that such cells are deprived of a normal supply of oxygen. Researchers believe that without sufficient oxygen, [...]

Auhtors: Hanahan D, Weinberg RA DOI:https://doi.org/10.1016/S0092-8674(00)81683-9 Abstract After a quarter century of rapid advances, cancer research has generated a rich and complex body of knowledge, revealing cancer to be a disease involving dynamic changes in the genome. The foundation has been set in the discovery of mutations that produce oncogenes with dominant gain of function [...]

Auhtors: Lengauer C, Kinzler KW, Vogelstein B PMID: 9872311 DOI: 10.1038/25292 Abstract Whether and how human tumours are genetically unstable has been debated for decades. There is now evidence that most cancers may indeed be genetically unstable, but that the instability exists at two distinct levels. In a small subset of tumours, the instability is [...]

Auhtors: Szent-Gyorgyi A PMID: 268635 PMCID: PMC431314 DOI: 10.1073/pnas.74.7.2844 Abstract Complex living structures developed on our globe after the appearance of light and oxygen. In functions of these structures, solid state phenomena play a major role. The structural proteins were made into radicals by doping, the covalent incorporation of electron acceptors. This lent mobility to [...]

Auhtors: Warburg O PMID: 13298683 DOI: 10.1126/science.123.3191.309 Keywords: cancer, cancer cells Source: https://pubmed.ncbi.nlm.nih.gov/13298683/ Archive: https://archive.ph/Pj9RD

Auhtors: Roskelley RC, Mayer N, Horwitt BN, Salter WT PMID: 16695058 PMCID: PMC435291 DOI: 10.1172/JCI101447 Keywords: cancer, enzyme deficiency Source: https://pubmed.ncbi.nlm.nih.gov/16695058/ Archive: https://archive.ph/te6PD