Auhtors: Watson J Abstract THE National Cancer Institute, which has overseen American efforts on researching and combating cancers since 1971, should take on an ambitious new goal for the next decade: the development of new drugs that will provide lifelong cures for many, if not all, major cancers. Beating cancer now is a realistic ambition [...]

Auhtors: Vander Heiden MG, Cantley LC, Thompson CB PMID: 19460998 PMCID: PMC2849637 DOI: 10.1126/science.1160809 Abstract In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect." Aerobic glycolysis is an inefficient [...]

Auhtors: Kilkkinen A, Rissanen H, Klaukka T, Pukkala E, Heliövaara M, Huovinen P, et al. PMID: 18704945 DOI: 10.1002/ijc.23622 Abstract Antibiotic use has been hypothesized to be associated with the risk of cancer but the evidence is sparse and inconsistent. The aim of the present study was to determine whether antibiotic use predicts the development [...]

Auhtors: Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN PMID: 18703489 PMCID: PMC2582368 DOI: 10.1194/jlr.M800319-JLR200 Abstract Otto Warburg first proposed that cancer originated from irreversible injury to mitochondrial respiration, but the structural basis for this injury has remained elusive. Cardiolipin (CL) is a complex phospholipid found almost exclusively in the inner mitochondrial membrane [...]

Auhtors: Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ PMID: 18287387 DOI: 10.3322/CA.2007.0010 Abstract Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and [...]

Authors: Vapiwala N, Mick R, Hampshire MK, Metz JM, DeNittis AS PMID: 17207316 DOI: 10.1097/00130404-200611000-00006 Abstract Purpose: Complementary and alternative medicine use is prevalent in both healthy and oncologic populations. However, few data exist to quantify complementary and alternative medicine initiation specifically after cancer diagnosis. This study evaluated patients' complementary and [...]

Auhtors: Martin RM, Middleton N, Gunnell D, Owen CG, Smith GD PMID: 16204694 DOI: 10.1093/jnci/dji291 Abstract Background: Having been breast-fed has been suggested to influence cancer risk in adulthood. We investigated associations between breast-feeding during infancy and adult cancer incidence and mortality in a cohort study and meta-analyses of published studies. Methods: The Boyd Orr [...]

Auhtors: Ramanathan A, Wang C, Schreiber SL PMID: 15840712 PMCID: PMC1087961 DOI: 10.1073/pnas.0502267102 Abstract Weinberg and coworkers have used serial transduction of a human, primary fibroblast cell line with the catalytic domain of human telomerase, large T antigen, small T antigen, and an oncogenic allele of H-ras to study stages leading toward a fully transformed [...]

Auhtors: Merrill RM, Fugal S, Novilla LB, Raphael MC PMID: 15721398 DOI: 10.1016/j.ygyno.2004.11.038 Abstract Objective: This paper provides a review of the literature associating maternal age at first birth and cancer. Potential mechanisms explaining associations between maternal age at first birth and cancer are also discussed. Method: Systematic review of English language literature using searches [...]

Auhtors: Yates JS, Mustian KM, Morrow GR, Gillies LJ, Padmanaban D, Atkins JN, et al. PMID: 15711946 DOI: 10.1007/s00520-004-0770-7 Abstract Goals of work: To assess complementary and alternative medicine (CAM) therapies being utilized by cancer patients during treatment and communication about CAM usage between the patient and physician. Patients and methods: Newly diagnosed cancer patients [...]