Auhtors: Marinac CR, Nelson SH, Breen CI, Hartman SJ, Natarajan L, Pierce JP, et al. PMID: 27032109 PMCID: PMC4982776 DOI: 10.1001/jamaoncol.2016.0164 Abstract Importance: Rodent studies demonstrate that prolonged fasting during the sleep phase positively influences carcinogenesis and metabolic processes that are putatively associated with risk and prognosis of breast cancer. To our knowledge, no studies [...]

Auhtors: Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhytyak Z, Cho C PMID: 26717410 PMCID: PMC4696735 DOI: 10.1371/journal.pbio.1002330 Abstract During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional [...]

Auhtors: Lahart IM, Metsios GS, Nevill AM, Carmichael AR PMID: 25752971 DOI: 10.3109/0284186X.2014.998275 Abstract Strong evidence exists supporting the effect of lack of physical activity on the risk of developing breast cancer. However, studies examining the effects of physical activity on breast cancer outcomes, including survival and prognosis have been inconclusive. Therefore, the aim of [...]

Auhtors: Chen Q, Zhang XH, Massagu J PMID: 22014578 PMCID: PMC3293160 DOI: 10.1016/j.ccr.2011.08.025 Abstract Aberrant expression of vascular cell adhesion molecule-1 (VCAM-1) in breast cancer cells is associated with lung relapse, but the role of VCAM-1 as a mediator of metastasis has remained unknown. We report that VCAM-1 provides a survival advantage to breast cancer [...]

Auhtors: Beasley JM, Kwan ML, Chen WY, Weltzien EK, Kroenke CH, Lu W, et al. PMID: 21935600 PMCID: PMC3272362 DOI: 10.1007/s10549-011-1770-1 Abstract The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk of morbidity and mortality. This [...]

Auhtors: Chen X, Lu W, Zheng W, Gu K, Matthews CE, Chen Z, et al. PMID: 21795422 PMCID: PMC3169008 DOI: 10.1158/1940-6207.CAPR-10-0355 Abstract It has been suggested that exercise following breast cancer diagnosis is inversely associated with mortality. However, controversy exists regarding the causality of such associations. We evaluated associations of exercise after breast cancer diagnosis [...]

Auhtors: Proietti S, Cucina A, D'Anselmi F, Dinicola S, Pasqualato A, Lisi E, Bizzarri M PMID: 21091766 DOI: 10.1111/j.1600-079X.2010.00824.x Abstract Melatonin and vitamin D3 inhibit breast cancer cell growth and induce apoptosis, but they have never been combined as a breast cancer treatment. Therefore, we investigated whether their association could lead to an enhanced anticancer [...]

Auhtors: Braun S, Vogl FD, Naume B, Janni W, Osborne MP, Coombes RC, et al. PMID: 16120859 DOI: 10.1056/NEJMoa050434 Abstract Background: We assessed the prognostic significance of the presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis. Methods: We combined individual patient data [...]

Auhtors: Lasalvia-Prisco E, Cucchi S, Vázquez J, Lasalvia-Galante E, Golomar W, Gordon W. PMID: 14655024 DOI: 10.1007/s00280-003-0716-7 Abstract Purpose: It has been reported that insulin increases the cytotoxic effect in vitro of methotrexate by as much as 10,000-fold. The purpose of this study was to explore the clinical value of insulin as a potentiator of [...]

Auhtors: MacMahon B, Cole PE, Lin TM, Lowe CR, Mirra AP PMID: 5312521 PMCID: PMC2427645 Abstract An international collaborative study of breast cancer and reproductive experience has been carried out in 7 areas of the world. In all areas studied, a striking relation between age at first birth and breast cancer risk was observed. It [...]