Authors: Marik PE PMID: 30312231 DOI: 10.1097/CCM.0000000000003336 Keywords: delirium, sepsis, septic shock, thiamine, Wernicke’s Source: https://journals.lww.com/ccmjournal/citation/2018/11000/thiamine__an_essential_component_of_the_metabolic.23.aspx Archive: https://archive.ph/z98Jx

Authors: Woolum JA, Abner EL, Kelly A, Thompson Bastin ML, Morris PE, Flannery AH. PMID: 30028362 DOI: 10.1097/CCM.0000000000003311 Abstract Objectives: Mounting evidence has shown that critically ill patients are commonly thiamine deficient. We sought to test the hypothesis that critically ill patients with septic shock exposed to thiamine would demonstrate improved lactate clearance and more [...]

Authors: Stephenson E, Hooper MH, Marik PE DOI:https://doi.org/10.1016/j.chest.2018.08.232 Abstract PURPOSE: The use of intravenous vitamin C for sepsis is increasing. Vitamin C interferes with point-of-care (POC) glucose monitoring devices that use the glucose-dehydrogenase method of testing (e.g. Accu-Chek, Roche, Indianapolis, IN). Spuriously elevated POC glucose levels have been reported in patients with burns after large [...]

Authors: Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A PMID: 29884817 PMCID: PMC5993715 DOI: 10.1038/s41467-018-04574-1 Abstract Inhaled corticosteroids (ICS) have limited efficacy in reducing chronic obstructive pulmonary disease (COPD) exacerbations and increase pneumonia risk, through unknown mechanisms. Rhinoviruses precipitate most exacerbations and increase susceptibility to secondary bacterial infections. Here, we show that the [...]

Authors: Saba A, Vaidya PJ, Chavhan VB, Achlerkar A, Leuppi J PMID: 32476885 PMCID: PMC7170064 DOI: 10.36141/svdld.v35i1.6393 Abstract There are no specific data on the management of pulmonary fibrosis post-H1N1 ARDS. We present the cases of three patients who responded positively to treatment with pirfenidone, azithromycin and prednisolone. Three males, aged 40, 45 and 59 [...]

Authors: Marik PE PMID: 29684467 DOI: 10.1016/j.pharmthera.2018.04.007 Abstract Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions. Sepsis results in the overwhelming production of reactive oxygen species with [...]

Authors: Cloutier N, Allaeys I, Marcoux G, Machius KR, Mailhot B PMID: 29386381 PMCID: PMC5816207 DOI: 10.1073/pnas.1720553115 Abstract There is a growing appreciation for the contribution of platelets to immunity; however, our knowledge mostly relies on platelet functions associated with vascular injury and the prevention of bleeding. Circulating immune complexes (ICs) contribute to both chronic [...]

Authors: Torrealba JR, Fisher S, Kanne JP, Butt YM, Glazer C, Kershaw C PMID: 29122655 DOI: 10.1016/j.humpath.2017.10.028 Abstract Organizing pneumonia (OP) is a common pattern of lung injury that can be associated with a wide range of etiologies. Typical and not-so-typical imaging features of OP occur, as both common and rare lung pathologies can mimic [...]

Authors: Barabutis N, Khangoora V, Marik PE, Catravas JD PMID: 28739448 PMCID: PMC5812759 DOI: 10.1016/j.chest.2017.07.014 Abstract Background: Sepsis refers to the dysregulated host immune response elicited by microbial infections resulting in life-threatening organ dysfunction. Sepsis represents a medical challenge, since it is associated with a rate of death as high as 60%. Septic shock is [...]

Authors: Kunutsor SK, Seidu S, Blom AW, Khunti K PMID: 28718029 PMCID: PMC5591345 DOI: 10.1007/s10654-017-0277-4 Abstract Evolving debate suggests that C-reactive protein (CRP) might be associated with the development of venous thromboembolism (VTE); however, the evidence is conflicting. We aimed to assess the prospective association of CRP with VTE risk. C-reactive protein was measured in [...]