Authors: Pan F, Ye T, Sun P, Gui S, Liang B, Li L PMID: 32053470 PMCID: PMC7233367 DOI: 10.1148/radiol.2020200370 Abstract Background Chest CT is used to assess the severity of lung involvement in coronavirus disease 2019 (COVID-19). Purpose To determine the changes in chest CT findings associated with COVID-19 from initial diagnosis until patient recovery. [...]

Authors: Moskowitz A, Donnino MW PMID: 32148929 PMCID: PMC7024754 DOI: 10.21037/jtd.2019.12.82 Abstract Thiamine (vitamin B1) is a water-soluble vitamin essential for human health. Thiamine deficiency is causal and/or contributory in a number of debilitating diseases including beri-beri, the Wernicke-Korsakoff syndrome, optic neuropathy, and others. While thiamine deficiency is relatively rare in developed nations as a [...]

Authors: Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al. PMID: 31986264 PMCID: PMC7159299 DOI: 10.1016/S0140-6736(20)30183-5 Abstract Background: A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and [...]

Authors: Colunga Biancatelli RM, Berrill M, Marik PE PMID: 31852327 DOI: 10.1080/14787210.2020.1706483 Abstract There is a growing interest in the administration of vitamin C beyond the treatment of hypovitaminosis C in malnourished patients. This has been driven by a 2016 ‘before-after’ study which suggested a substantial survival benefit from a protocol that included hydrocortisone, ascorbic [...]

Authors: Huang X, Han S, Liu x, Wang T, Xu H PMID: 32010252 PMCID: PMC6966138 DOI: 10.3892/etm.2019.8285 Abstract Sepsis commonly progresses to disseminated intravascular coagulation and induces the activation of heparanase (HPA) and the shedding of endothelial glycocalyx constituents, including syndecan-1 (SDC-1) and heparan sulphate (HS). However, the degradation of glycocalyx and its association with [...]

Authors: Howell AP, Parrett JL, Malcom DR PMID: 31766883 PMCID: PMC8256056 DOI: 10.1177/1932296819889638 Abstract Background: Intravenous vitamin C therapy has been associated with reduced mortality in patients with sepsis. Of potential concern with this therapy are falsely elevated point-of-care (POC) blood glucose values vs laboratory analyzed (LA) readings. The purpose of this study was to [...]

Authors: Fowler AA, Truwit JD, Hite D, Morris PE, DeWilde C, Priday A et al. PMID: 31573637 PMCID: PMC6777268 DOI: 10.1001/jama.2019.11825 Abstract Importance: Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis and acute respiratory distress syndrome (ARDS). Objective: To determine the effect of intravenous vitamin C infusion [...]

Authors: Brouwer WP, Duran S, Kuijper M, Inc C PMID: 31533846 PMCID: PMC6749645 DOI: 10.1186/s13054-019-2588-1 Abstract Background and aims: Innovative treatment modalities have not yet shown a clinical benefit in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to continuous renal replacement therapy (CRRT) showed promising results in case reports. However, [...]

Authors: Wang Y, Lin H, Lin BW, Lin JD PMID: 31111241 PMCID: PMC6527630 DOI: 10.1186/s13613-019-0532-9 Abstract Background: Low levels of ascorbic acid (AA) have been detected in critically ill patients in which AA supplementation leads to promising outcomes. However, the ability of AA to reduce mortality in critically ill patients remains controversial. In this study, [...]

Authors: Marik PE PMID: 30441816 doi: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid [...]