Authors: Harasstaini OA, Moin S, Tham CL, Liew CY, Ismail N, Israf DA PMID: 20221843 DOI: 10.1007/s00011-010-0182-8 Abstract Objectives: We evaluated several flavonoid combinations for synergy in the inhibition of proinflammatory mediator synthesis in the RAW 264.7 cellular model of inflammation. Methods: The inhibitory effect of chrysin, kaempferol, morin, silibinin, quercetin, diosmin and hesperidin upon [...]

Authors: Ng WK, Rosenblatt Y, Brock GB, O'Gorman DB, Gan BS PMID: 21358864 PMCID: PMC2851459 Abstract The treatment of digital ischemia remains difficult. Sildenafil (Viagra, Pfizer UK), a selective phosphodiesterase inhibitor, increases blood flow and is currently marketed for the treatment of erectile dysfunction. A case of a 57-year-old man with progressive episodic ischemia and [...]

Abstract Endothelial barrier dysfunction contributes to morbidity in sepsis. We tested the hypothesis that raising the intracellular ascorbate concentration protects the endothelial barrier from septic insult by inhibiting protein phosphatase type 2A.

Authors: Chowanadisiai W, Bauerly KA, Tchaparian E, Wong A, Rucker RB PMID: 19861415 PMCID: PMC2804159 DOI: 10.1074/jbc.M109.030130 Abstract Bioactive compounds reported to stimulate mitochondrial biogenesis are linked to many health benefits such increased longevity, improved energy utilization, and protection from reactive oxygen species. Previously studies have shown that mice and rats fed diets lacking in [...]

Authors: MacDonald K, McDonald TM PMID: 20047458 DOI: 10.3109/10673220903523615 Abstract Oxytocin is a neuropeptide involved in a wide variety of social behaviors in diverse species. Recent research on its effects in humans has generated an arresting picture of its role in the dynamic function of the social brain. This review presents a broad overview of [...]

Authors: Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Madeo F PMID: 20157579 PMCID: PMC2815753 DOI: 10.18632/aging.100110 Abstract Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced [...]

Authors: Langguth B PMID: 19931642 DOI: 10.1016/j.drudis.2009.11.003 Abstract Tinnitus is the conscious perception of a phantom sound in the absence of an external source. For 1 in 100 of the general population, the condition severely affects quality of life. In spite of the fact that the market for a drug indicated for tinnitus relief is [...]

Authors: Griffith RS, Norins AL, Kagan C PMID: 640102 DOI: 10.1159/000250926 Abstract Lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312-1,200 mg of lysine daily in single or multiple doses. The clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from [...]

Authors: Griffith RS, Wlash DE, Myrmel KH, Thompson RW PMID: 3115841 Abstract A double-blind, placebo-controlled, multicenter trial of oral L-lysine monohydrochloride for the prevention and treatment of recurrent herpes simplex (HSV) infection was conducted. The treatment group was given L-Lysine monohydrochloride tablets (1,000 mg L-lysine per dose) 3 times a day for 6 months. A [...]

Authors: Eisenberg T, Knauer H, Schauer A, Buttner S, Carmona-Gutierrez D, Ring J et al. PMID: 19801973 DOI: 10.1038/ncb1975 Abstract Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose [...]