Authors: Kiechl S, Pechlaner R, Willeit P, Notdurfier M, Paulweber B, Willeit K et al. PMID: 29955838 DOI: 10.1093/ajcn/nqy102 Abstract Background: Spermidine administration is linked to increased survival in several animal models. Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans. Design: This [...]

Authors: Langguth B, Elgoyhen AB, Cederroth CR PMID: 30044727 DOI: 10.1146/annurev-pharmtox-010818-021556 Abstract Tinnitus is a highly prevalent condition that is associated with hearing loss in most cases. In the absence of external stimuli, phantom perceptions of sounds emerge from alterations in neuronal activity within central auditory and nonauditory structures. Pioneering studies using lidocaine revealed that [...]

Authors: Wang YH, Li SA, Huang CH, Su HH, Chen YH PMID: 29962953 PMCID: PMC6013847 DOI: 10.3389/fphar.2018.00636 Abstract Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, and to treat cardiovascular diseases in clinical for more than 10 years. Up until now, the mechanism of the cardioprotective effects of post-ischemic [...]

Authors: Servy EJ, Jacquesson-Fournols L, Cohen M, Menezo YJ PMID: 29882091 PMCID: PMC6086798 DOI: 10.1007/s10815-018-1225-2 Abstract Purpose: To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by supplementation with 5-methyl THF instead of synthetic folic acid. In these couples, high doses [...]

Authors: Mutz J, Edgcumbe DR, Brunoni AR, Fu CH PMID: 29763711 DOI: 10.1016/j.neubiorev.2018.05.015 Abstract We examined the efficacy and acceptability of non-invasive brain stimulation in adult unipolar and bipolar depression. Randomised sham-controlled trials of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and theta-burst stimulation (TBS), without co-initiation of another treatment, were included. We [...]

Authors: Marik PE PMID: 29684467 DOI: 10.1016/j.pharmthera.2018.04.007 Abstract Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions. Sepsis results in the overwhelming production of reactive oxygen species with [...]

Authors: Falkenberg RI, Eising C, Peters ML PMID: 29429046 DOI: 10.1007/s10865-018-9914-y Abstract Yoga is an ancient mind-body practice that is increasingly recognized to have health benefits in a variety of clinical and non-clinical conditions. This systematic review summarizes the findings of randomized controlled trials examining the effects of yoga on immune system functioning which is [...]

Authors: Han CH, Zhang PX, Xu WG, Li RP PMID: 29497483 PMCID: PMC5806443 DOI: 10.4103/2045-9912.215749 Abstract The veins are a major site of bubble formation after decompression and the lung is a target organ of bubbles. Bubble-induced inflammation has been implicated in the pathogenesis of decompression sickness (DCS). Macrophages play a central role in the [...]

Authors: Sanna A, Firinu D, Zavattari P, Valera P PMID: 29324654 PMCID: PMC5793296 DOI: 10.3390/nu10010068 Abstract Zinc is an essential trace element for living organisms and their biological processes. Zinc plays a key role in more than 300 enzymes and it is involved in cell communication, proliferation, differentiation and survival. Zinc plays also a role [...]

Authors: Keihanian F, Saeidinia A, Bagheri RK, Johnston TP, Sahebkar A PMID: 29052850 DOI: 10.1002/jcp.26249 Abstract Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help [...]