Authors: Bharath LP, Agrawal M, McCambridge G, Nichols DA, Hasturk H, Liu J et al. PMID: 32402267 PMCID: PMC7217133 DOI: 10.1016/j.cmet.2020.04.015 Abstract Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates [...]

Authors: Theoharides TC PMID: 32339387 PMCID: PMC7267424 DOI: 10.1002/biof.1633 Abstract The new coronavirus (severe acute pulmonary syndrome [SARS]‐CoV‐2) originated in China, where it spread rapidly, and has reached pandemic proportions because of its high rate of infectivity as well as high morbidity and mortality, associated with COVID‐19. This coronavirus infects by first binding to the [...]

Authors: Abdelnour L, Abdalla ME, Babiker S PMID: 32354690 PMCID: PMC7183987 DOI: 10.1016/j.jfma.2020.04.024 Abstract On Mar 23, 2020, a 69-year-old man presented to the Ulster Hospital in Northern Ireland after waking up with bilateral lower limb weakness three days prior to admission. He had numbness on both legs that lasted for hours and resolved. He [...]

Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H. PMID: 12431781 DOI: 10.1016/s0167-4889(02)00328-2 Abstract Flavonoids are plant metabolites that are dietary antioxidants and exert significant anti-tumor, anti-allergic, anti-inflammatory and anti-viral effects. It is generally accepted that Th-1 derived cytokines such as IL-2, IFNgamma and IL-12 promote cellular immunity while Th-2 derived [...]

Authors: Diep PT, Buemann B, Uvnas-Moberg K PMID: 34908992 PMCID: PMC8629037 DOI: 10.36131/CNEPUB20201703 Abstract After comparing the morbidity patterns of COVID-19 infections, variations of oxytocin levels and some properties of the neurohormone oxytocin, the authors put forward their hypothesis that oxytocin might constitute a safe, inexpensive and readily available treatment for this disease. Keywords: COVID-19, [...]

Authors: Gassen NC, Papies J, Bajaj T, Emanuel J, Wechmann K, Heinz DE et al. doi: https://doi.org/10.1101/2020.04.15.997254 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available. Pharmacological modulation of metabolism-dependent cellular pathways such as autophagy [...]

Authors: Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA PMID: 32319538 PMCID: PMC7255455 DOI: 10.3892/ijmm.2020.4575 Abstract In view of the emerging COVID‑19 pandemic caused by SARS‑CoV‑2 virus, the search for potential protective and therapeutic antiviral strategies is of particular and urgent interest. Zinc is known to modulate antiviral and antibacterial immunity and regulate [...]

Authors: Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL et al. PMID: 32268299 PMCID: PMC7185103 DOI: 10.18632/aging.103035 Abstract The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this [...]

Authors: Tezgin D, Giardina C, Perdrizet GA, Hightower LE PMID: 32253741 PMCID: PMC7332662 doi: 10.1007/s12192-020-01100-5 Abstract We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of [...]

Authors: Keith P, Day M, Perkins L, Moyer L, Hewitt K, Wells A PMID: 32241301 PMCID: PMC7117947 DOI: 10.1186/s13054-020-2836-4 Abstract The novel coronavirus (“SARS-CoV-2”) outbreak has created a sense of panic globally and has the medical community rapidly searching for answers. An estimated 100,000 individuals have already been infected with nearly 3300 deaths attributed to [...]