Authors: Derosa G, Maffioli P, D'Angelo A, Di Pierro F PMID: 33034398 PMCID: PMC7675685 DOI: 10.1002/ptr.6887 Abstract Several months ago, an outbreak of pneumonia of unknown aetiology was detected in Wuhan City (China) and the aetiological agent of the atypical pneumonia was isolated by the Chinese authorities as novel coronavirus (2019-nCoV or SARS-CoV-2). The WHO [...]

Authors: Lehrer S, Rheinstein PH PMID: 32871846 PMCID: PMC7652439 DOI: 10.21873/invivo.12134 Abstract Background/aim: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One drug that has attracted interest is the antiparasitic compound ivermectin, a macrocyclic lactone derived from the bacterium Streptomyces avermitilis. We carried out a docking [...]

Authors: DiNicolantonio JJ, Barroso-Arranda J, McCarty M PMID: 32895293 PMCID: PMC7476419 DOI: 10.1136/openhrt-2020-001350 Abstract Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including river blindness and lymphatic filariasis. It is also widely [...]

Authors: Schiaffino MT, Di Natale M, Garcia-Martinez E, Navarro J, Munoz-Blanco JL, Demelo-Rodriguez P PMID: 32738141 PMCID: PMC7454719 DOI: 10.1093/infdis/jiaa485 Abstract Background: During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients. Methods: The IF pattern was composed of liver and gastric [...]

Authors: Senniappan K, Jeyabalan S, Rangappa P, Kanchi M PMID: 33437070 PMCID: PMC7791429 DOI: 10.4103/ija.IJA_613_20 Abstract The coronavirus disease 2019 (COVID-19) is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Although 85% of infected patients remain asymptomatic, 5% show severe symptoms such as hypoxaemic respiratory failure and multiple end organ dysfunction (MODS) [...]

Authors: Han AY, Mukdad L, Long JL, Lopez IA PMID: 32914699 PMCID: PMC7488171 DOI: 10.1177/1073858420956905 Abstract In recent months it has emerged that the novel coronavirus-responsible for the COVID-19 pandemic-causes reduction of smell and taste in a large fraction of patients. The chemosensory deficits are often the earliest, and sometimes the only signs in otherwise [...]

Authors: Afrin LB, Weinstock LB, Molderings GJ PMID: 32920235 PMCID: PMC7529115 DOI: 10.1016/j.ijid.2020.09.016 Abstract Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2. Although only recently recognized, MC activation syndrome (MCAS), usually due to acquired MC clonality, is a [...]

Authors: Karst M, Hollenhorst J, Achenbach J PMID: 33254541 PMCID: PMC7467063 DOI: 10.1016/j.mehy.2020.110234 Abstract As the current COVID-19 pandemic develops and epidemiological data reveals differences in geographical spread as well as risk factors for developing a severe course of illness, hypotheses regarding possible underlying mechanisms need to be developed and tested. In our hypothesis, we [...]

Authors: van Eeden C, Khqn L, Osman MS, Tevaert JW PMID: 32883007 PMCID: PMC7503862 DOI: 10.3390/ijms21176351 Abstract When facing an acute viral infection, our immune systems need to function with finite precision to enable the elimination of the pathogen, whilst protecting our bodies from immune-related damage. In many instances however this "perfect balance" is not [...]

Authors: Chen JJ, Zeng BS, Wu CN, Stubbs B, Carvalho AF, Su KP PMID: 32644131 PMCID: PMC7349076 DOI: 10.1001/jamaoto.2020.1497 Abstract Importance: Tinnitus has a prevalence of 10% to 25% and is frequently associated with numerous complications, such as neuropsychiatric disease. Traditional treatments have failed to meet the needs of patients with tinnitus. Noninvasive brain stimulation [...]