Authors:Borsche L, Glauner B, von Mendel J. PMID:PMC8541492 DOI: 10.3390/nu13103596 Abstract Background: Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further [...]

Authors: Hazan S, Stollman N, Bozkurt H, Dave S, Daniels J, Borody TJ. doi: https://doi.org/10.1101/2021.09.02.21262832 Abstract Objective To compare gut microbiome diversity and composition in SARS-CoV-2 polymerase chain reaction (PCR)-confirmed positive patients whose symptoms ranged from asymptomatic to severe versus PCR-negative exposed controls. Design Using a cross-sectional study design, we used shotgun next-generation sequencing (NGS) [...]

Authors: Morgenstern J, Redondo JN, Olavarria A, Rondon I, Roca S, De Leon A et al. PMID: PMC8405705 DOI: 10.7759/cureus.17455 Abstract Background: Ivermectin is a drug that has been shown to be active against coronavirus disease 19 (COVID-19) in previous studies. Healthcare personnel are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. [...]

Treatment for coronavirus disease 2019 (COVID19) pneumonia remains empirical and the search for therapies that can improve outcomes continues. Melatonin has been shown to have anti-inflammatory, antioxidant, and immune-modulating effects that may address key pathophysiologic mechanisms in the development and progression of acute respiratory distress syndrome (ARDS), which has been implicated as the likely cause of death in COVID19. We aimed to describe the observable clinical outcomes and tolerability of high-dose melatonin (hdM) given as adjuvant therapy in patients admitted with COVID19 pneumonia.

Authors: Wu Y, Cheng X, Jiang G, Tang H, Ming S. PMID: 34911943 PMCID: PMC8672330 DOI: 10.1038/s41522-021-00262-z Abstract The human oral and gut commensal microbes play vital roles in the development and maintenance of immune homeostasis, while its association with susceptibility and severity of SARS-CoV-2 infection is barely understood. In this study, we investigated the [...]

Authors:Cozier YC, Castro-Webb N, Hochberg NS, Rosenberg L, Albert MA, Palmer JR. PMID: PMC8315514 DOI: 10.1371/journal.pone.0255132 Abstract Objective: Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection. Black women commonly experience 25(OH)D insufficiency and are overrepresented among COVID-19 cases. We conducted a prospective [...]

Authors:Farnoosh G, Akbaariqomix M, Badri T, Bagheri M, Izadi M. PMID: PMC8220995 DOI: 10.1016/j.arcmed.2021.06.006 Abstract Background: Melatonin has been known as an anti-inflammatory agent and immune modulator that may address progressive pathophysiology of coronavirus disease 2019 (COVID-19). Aim of the study: To evaluate the clinical efficacy of adjuvant, use of melatonin [...]

Authors: Ahmadi R, Salari S, Reihani H, Eslami S. PMID: PMC8358331 DOI: 10.1002/fsn3.2226 Abstract Background: Curcumin, a natural polyphenolic compound, is proposed as a potential treatment option for patients with coronavirus disease by inhibiting the entry of virus to the cell, encapsulation of the virus and viral protease, as well as modulating various cellular signaling [...]

Authors: Khazdair MR, Ghafari S, Sadeghi M. PMID: PMC8204995 doi: 10.1080/13880209.2021.1931353 Abstract Context COVID-19 is a novel coronavirus that causes a severe infection in the respiratory system. Nigella sativa L. (Ranunculaceae) is an annual flowering plant used traditionally as a natural food supplement and multipurpose medicinal agent. Objective The possible beneficial effects of N. sativa, [...]

Authors: Ohgitani E, Shin-Ya M, Ichitani M, Kobayashi M, Takihara T. PMID: 34201131 PMCID: PMC8227886 DOI: 10.3390/pathogens10060721 Abstract Saliva plays major roles in the human-to-human transmission of SARS-CoV-2. If the virus in saliva in SARS-CoV-2-infected individuals can be rapidly and efficiently inactivated by a beverage, the ingestion of the beverage may attenuate the spread of [...]